FGF19 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FGF19 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FGF19 at tissue level.

III. Associated gene sets

GO_0046326Biological processpositive regulation of glucose import
GO_0070858Biological processnegative regulation of bile acid biosynthetic process
GO_0010629Biological processnegative regulation of gene expression
GO_0046330Biological processpositive regulation of JNK cascade
GO_0009887Biological processanimal organ morphogenesis
GO_0010628Biological processpositive regulation of gene expression
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0030154Biological processcell differentiation
GO_0030334Biological processregulation of cell migration
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0007399Biological processnervous system development
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005737Cellular componentcytoplasm
GO_0008083Molecular functiongrowth factor activity
GO_0005104Molecular functionfibroblast growth factor receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFGF19
Protein nameFibroblast growth factor 19 (FGF-19)
Fibroblast growth factor (FGF)
SynonymshCG_1646998
FGF8A
UNQ334/PRO533
DescriptionFUNCTION: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. .

AccessionsO95750
ENST00000294312.4
A0A7U3L4E7