INPPL1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of INPPL1 at tissue level.

III. Associated gene sets

GO_0002376Biological processimmune system process
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0006897Biological processendocytosis
GO_0009791Biological processpost-embryonic development
GO_0010629Biological processnegative regulation of gene expression
GO_0032868Biological processresponse to insulin
GO_0046856Biological processphosphatidylinositol dephosphorylation
GO_0007155Biological processcell adhesion
GO_0097178Biological processruffle assembly
GO_0001958Biological processendochondral ossification
GO_0050776Biological processregulation of immune response
GO_0070371Biological processERK1 and ERK2 cascade
GO_0007015Biological processactin filament organization
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0043569Biological processnegative regulation of insulin-like growth factor receptor signaling pathway
GO_0006915Biological processapoptotic process
GO_0010467Biological processgene expression
GO_0006006Biological processglucose metabolic process
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0000922Cellular componentspindle pole
GO_0016607Cellular componentnuclear speck
GO_0005794Cellular componentGolgi apparatus
GO_0009925Cellular componentbasal plasma membrane
GO_0030175Cellular componentfilopodium
GO_0005829Cellular componentcytosol
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0034485Molecular functionphosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO_0003779Molecular functionactin binding
GO_0042169Molecular functionSH2 domain binding
GO_0004445Molecular functioninositol-polyphosphate 5-phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameINPPL1
Protein nameInositol polyphosphate phosphatase like 1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)
SynonymsSHIP2
DescriptionFUNCTION: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways . Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear . While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling . Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation . Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling . Regulates cell adhesion and cell spreading . Required for HGF-mediated lamellipodium formation, cell scattering and spreading . Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation . Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) . Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems . Involved in EGF signaling pathway . Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 . Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity . Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification . .

AccessionsENST00000540329.5
F5GY16
H7BXR2
F5GWY9
ENST00000538751.5 [O15357-2]
F5GYK9
ENST00000320683.7
O15357
H0YFB4
ENST00000537656.1
H0YFZ4
ENST00000535985.1
ENST00000543234.1
ENST00000541752.1
F5H588
ENST00000298229.7 [O15357-1]
ENST00000540973.1