ID3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042476Biological processodontogenesis
GO_0010629Biological processnegative regulation of gene expression
GO_0030855Biological processepithelial cell differentiation
GO_0007507Biological processheart development
GO_0045662Biological processnegative regulation of myoblast differentiation
GO_0001656Biological processmetanephros development
GO_0010628Biological processpositive regulation of gene expression
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0072750Biological processcellular response to leptomycin B
GO_0032922Biological processcircadian regulation of gene expression
GO_0030182Biological processneuron differentiation
GO_0030154Biological processcell differentiation
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0007517Biological processmuscle organ development
GO_0007417Biological processcentral nervous system development
GO_0006275Biological processregulation of DNA replication
GO_0043065Biological processpositive regulation of apoptotic process
GO_0030903Biological processnotochord development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0043425Molecular functionbHLH transcription factor binding
GO_1901707Molecular functionleptomycin B binding
GO_0019904Molecular functionprotein domain specific binding
GO_0140416Molecular functiontranscription regulator inhibitor activity
GO_0140110Molecular functiontranscription regulator activity
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameID3
Protein nameDNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3)
Synonyms1R21
BHLHB25
HEIR1
DescriptionFUNCTION: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. .

AccessionsQ02535
ENST00000374561.6
ENST00000634790.2