TP53INP1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TP53INP1 at tissue level.

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0009408Biological processresponse to heat
GO_0098869Biological processcellular oxidant detoxification
GO_0048147Biological processnegative regulation of fibroblast proliferation
GO_0071447Biological processcellular response to hydroperoxide
GO_1904761Biological processnegative regulation of myofibroblast differentiation
GO_0010629Biological processnegative regulation of gene expression
GO_0034644Biological processcellular response to UV
GO_0000045Biological processautophagosome assembly
GO_0071361Biological processcellular response to ethanol
GO_0010628Biological processpositive regulation of gene expression
GO_0048102Biological processautophagic cell death
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0010508Biological processpositive regulation of autophagy
GO_0006915Biological processapoptotic process
GO_0072703Biological processcellular response to methyl methanesulfonate
GO_0030336Biological processnegative regulation of cell migration
GO_0043065Biological processpositive regulation of apoptotic process
GO_0051726Biological processregulation of cell cycle
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0005776Cellular componentautophagosome
GO_0005634Cellular componentnucleus
GO_0016209Molecular functionantioxidant activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTP53INP1
Protein nameTumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1)
SynonymsP53DINP1
SIP
DescriptionFUNCTION: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. .

AccessionsENST00000342697.5 [Q96A56-1]
Q96A56
ENST00000448464.6 [Q96A56-2]