I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| transit amplifying cell | 3 studies | 50% ± 27% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| transit amplifying cell | 3 studies | 50% ± 27% |
Insufficient scRNA-seq data for expression of BRIP1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 99% | 440.36 | 1794 / 1809 | 89% | 3.82 | 420 / 472 |
| ovary | 96% | 170.63 | 173 / 180 | 83% | 2.37 | 355 / 430 |
| stomach | 84% | 87.47 | 300 / 359 | 94% | 3.86 | 268 / 286 |
| bladder | 86% | 64.38 | 18 / 21 | 91% | 4.12 | 459 / 504 |
| lung | 87% | 99.26 | 501 / 578 | 88% | 3.87 | 1014 / 1155 |
| breast | 82% | 80.92 | 377 / 459 | 90% | 4.63 | 1007 / 1118 |
| esophagus | 64% | 142.15 | 927 / 1445 | 100% | 6.36 | 183 / 183 |
| uterus | 63% | 52.44 | 107 / 170 | 97% | 7.64 | 447 / 459 |
| intestine | 66% | 115.16 | 639 / 966 | 93% | 3.58 | 490 / 527 |
| liver | 77% | 98.64 | 175 / 226 | 55% | 1.41 | 225 / 406 |
| pancreas | 56% | 33.50 | 183 / 328 | 54% | 1.48 | 97 / 178 |
| adrenal gland | 81% | 61.05 | 208 / 258 | 23% | 0.46 | 53 / 230 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 9.06 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.62 | 1 / 1 |
| spleen | 97% | 115.27 | 233 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 3.55 | 28 / 29 |
| prostate | 80% | 61.23 | 196 / 245 | 16% | 0.30 | 81 / 502 |
| brain | 42% | 30.36 | 1117 / 2642 | 42% | 1.36 | 295 / 705 |
| adipose | 75% | 67.26 | 901 / 1204 | 0% | 0 | 0 / 0 |
| kidney | 30% | 21.64 | 27 / 89 | 33% | 0.64 | 293 / 901 |
| blood vessel | 53% | 29.39 | 706 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 50% | 438.17 | 461 / 929 | 0% | 0 | 0 / 0 |
| thymus | 18% | 10.78 | 117 / 653 | 21% | 0.73 | 127 / 605 |
| eye | 0% | 0 | 0 / 0 | 19% | 0.23 | 15 / 80 |
| heart | 7% | 4.38 | 62 / 861 | 0% | 0 | 0 / 0 |
| muscle | 4% | 1.84 | 30 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0032508 | Biological process | DNA duplex unwinding |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0006281 | Biological process | DNA repair |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0006302 | Biological process | double-strand break repair |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0006289 | Biological process | nucleotide-excision repair |
| GO_0071456 | Biological process | cellular response to hypoxia |
| GO_0051026 | Biological process | chiasma assembly |
| GO_0010705 | Biological process | meiotic DNA double-strand break processing involved in reciprocal meiotic recombination |
| GO_0072520 | Biological process | seminiferous tubule development |
| GO_0106300 | Biological process | protein-DNA covalent cross-linking repair |
| GO_0035825 | Biological process | homologous recombination |
| GO_1990918 | Biological process | double-strand break repair involved in meiotic recombination |
| GO_0007284 | Biological process | spermatogonial cell division |
| GO_0071295 | Biological process | cellular response to vitamin |
| GO_0009636 | Biological process | response to toxic substance |
| GO_0007286 | Biological process | spermatid development |
| GO_0000077 | Biological process | DNA damage checkpoint signaling |
| GO_1904385 | Biological process | cellular response to angiotensin |
| GO_0005657 | Cellular component | replication fork |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0070532 | Cellular component | BRCA1-B complex |
| GO_0031965 | Cellular component | nuclear membrane |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0003724 | Molecular function | RNA helicase activity |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0051539 | Molecular function | 4 iron, 4 sulfur cluster binding |
| GO_0003678 | Molecular function | DNA helicase activity |
| GO_0043139 | Molecular function | 5'-3' DNA helicase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| Gene name | BRIP1 |
| Protein name | BRCA1 interacting helicase 1 Fanconi anemia group J protein (EC 3.6.4.12) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) |
| Synonyms | FANCJ BACH1 |
| Description | FUNCTION: DNA-dependent helicase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability . Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination . Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 . Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease . . |
| Accessions | ENST00000684584.1 ENST00000584322.2 A0A804HHV8 ENST00000683381.1 A0A804HL36 Q9BX63 A0A804HLF1 ENST00000682369.1 ENST00000682453.1 [Q9BX63-1] ENST00000577598.5 [Q9BX63-2] A0A804HJU1 A0A804HJV4 ENST00000683672.1 ENST00000684769.1 A0A804HKK6 A0A804HK62 ENST00000682989.1 ENST00000579028.2 J3QKX0 A0A804HKS0 ENST00000683039.1 [Q9BX63-1] A0A804HIR6 A0A804HIH9 ENST00000683692.1 J3KS24 ENST00000259008.7 [Q9BX63-1] ENST00000577913.2 ENST00000682755.1 ENST00000682066.1 ENST00000682611.1 J3QQP5 A0A804HJY1 ENST00000683235.1 ENST00000682477.1 |
