Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| macrophage | 6 studies | 23% ± 3% | |
| myeloid cell | 4 studies | 26% ± 12% | |
| astrocyte | 4 studies | 24% ± 4% | |
| oligodendrocyte | 4 studies | 18% ± 3% | |
| endothelial cell | 3 studies | 21% ± 3% | |
| plasma cell | 3 studies | 26% ± 8% | |
| epithelial cell | 3 studies | 19% ± 3% | |
| GABAergic neuron | 3 studies | 38% ± 3% | |
| glutamatergic neuron | 3 studies | 49% ± 7% | |
| interneuron | 3 studies | 32% ± 15% | |
| oligodendrocyte precursor cell | 3 studies | 22% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 31% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 1884.07 | 653 / 653 | 100% | 9.88 | 604 / 605 |
| lung | 100% | 1329.10 | 577 / 578 | 100% | 7.16 | 1152 / 1155 |
| breast | 100% | 1365.08 | 458 / 459 | 100% | 9.72 | 1114 / 1118 |
| prostate | 100% | 1304.30 | 245 / 245 | 99% | 8.94 | 499 / 502 |
| skin | 100% | 1237.93 | 1809 / 1809 | 99% | 17.48 | 469 / 472 |
| kidney | 100% | 1273.33 | 89 / 89 | 99% | 9.26 | 892 / 901 |
| esophagus | 100% | 1017.68 | 1445 / 1445 | 99% | 7.36 | 181 / 183 |
| pancreas | 99% | 969.43 | 326 / 328 | 99% | 7.24 | 177 / 178 |
| brain | 99% | 766.10 | 2617 / 2642 | 100% | 6.01 | 702 / 705 |
| stomach | 100% | 1040.77 | 359 / 359 | 99% | 9.26 | 282 / 286 |
| intestine | 100% | 1399.87 | 966 / 966 | 98% | 8.72 | 515 / 527 |
| bladder | 100% | 1278.67 | 21 / 21 | 96% | 6.45 | 486 / 504 |
| adrenal gland | 99% | 1728.81 | 256 / 258 | 97% | 5.71 | 223 / 230 |
| uterus | 100% | 1515.66 | 170 / 170 | 96% | 6.14 | 441 / 459 |
| ovary | 100% | 2103.61 | 180 / 180 | 95% | 4.68 | 409 / 430 |
| liver | 99% | 646.40 | 224 / 226 | 88% | 4.31 | 359 / 406 |
| eye | 0% | 0 | 0 / 0 | 100% | 21.59 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 12.96 | 29 / 29 |
| spleen | 100% | 2233.70 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 6.19 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.75 | 1 / 1 |
| blood vessel | 100% | 1075.21 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 1129.18 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| heart | 98% | 970.37 | 840 / 861 | 0% | 0 | 0 / 0 |
| muscle | 85% | 339.64 | 683 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 80% | 764.82 | 745 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0070986 | Biological process | left/right axis specification |
| GO_0000278 | Biological process | mitotic cell cycle |
| GO_0032259 | Biological process | methylation |
| GO_0007059 | Biological process | chromosome segregation |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0001947 | Biological process | heart looping |
| GO_0090309 | Biological process | positive regulation of DNA methylation-dependent heterochromatin formation |
| GO_0051301 | Biological process | cell division |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0070828 | Biological process | heterochromatin organization |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005694 | Cellular component | chromosome |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0046974 | Molecular function | histone H3K9 methyltransferase activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0140938 | Molecular function | histone H3 methyltransferase activity |
| GO_0140948 | Molecular function | histone H3K9 monomethyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SETDB2 |
| Protein name | Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2) Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (SET domain bifurcated 2) |
| Synonyms | KMT1F C13orf4 CLLD8 |
| Description | FUNCTION: Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. . |
| Accessions | A0A087WYZ9 Q96T68 ENST00000611815.2 [Q96T68-2] ENST00000317257.12 [Q96T68-2] ENST00000354234.8 [Q96T68-1] ENST00000611815 |
