VHL | OmnibusX

Name	Number of supported studies	Average coverage
B cell	10 studies	21% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	18% ± 2%	Explore
naive B cell	7 studies	19% ± 3%	Explore
natural killer cell	7 studies	17% ± 1%	Explore
memory B cell	6 studies	19% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	18% ± 2%	Explore
classical monocyte	4 studies	22% ± 5%	Explore
epithelial cell	4 studies	27% ± 8%	Explore
dendritic cell	4 studies	27% ± 12%	Explore
CD4-positive, alpha-beta T cell	3 studies	20% ± 4%	Explore
non-classical monocyte	3 studies	25% ± 7%	Explore
GABAergic neuron	3 studies	24% ± 5%	Explore
glutamatergic neuron	3 studies	33% ± 10%	Explore
basal cell	3 studies	17% ± 1%	Explore
plasmacytoid dendritic cell	3 studies	17% ± 1%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	20% ± 4%	Explore
gamma-delta T cell	3 studies	23% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	5 studies	20% ± 4%	Explore
brain	4 studies	23% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1433.04	1445 / 1445	100%	27.72	183 / 183
thymus	100%	1866.72	653 / 653	100%	32.91	605 / 605
uterus	100%	1737.01	170 / 170	100%	36.46	459 / 459
breast	100%	1818.63	459 / 459	100%	37.80	1117 / 1118
intestine	100%	1779.51	966 / 966	100%	30.02	526 / 527
bladder	100%	1621.10	21 / 21	100%	41.59	503 / 504
prostate	100%	1752.62	245 / 245	100%	38.07	501 / 502
ovary	100%	1719.45	180 / 180	100%	26.54	429 / 430
brain	100%	1619.58	2633 / 2642	100%	38.71	705 / 705
lung	100%	1934.88	577 / 578	100%	25.91	1150 / 1155
stomach	100%	1238.86	359 / 359	99%	29.71	284 / 286
pancreas	100%	1126.60	327 / 328	99%	27.60	177 / 178
adrenal gland	100%	1945.57	258 / 258	97%	18.82	224 / 230
skin	100%	2116.35	1808 / 1809	97%	25.28	458 / 472
liver	100%	1078.10	226 / 226	97%	17.19	393 / 406
kidney	100%	1347.38	89 / 89	92%	14.98	832 / 901
adipose	100%	1649.40	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	53.68	29 / 29
spleen	100%	2663.72	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	48.86	1 / 1
blood vessel	100%	1218.13	1333 / 1335	0%	0	0 / 0
muscle	100%	913.81	801 / 803	0%	0	0 / 0
peripheral blood	98%	2488.86	912 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	31.98	44 / 45
heart	97%	817.48	834 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	66%	8.03	53 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016567	Biological process	protein ubiquitination
GO_0010468	Biological process	regulation of gene expression
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0046426	Biological process	negative regulation of receptor signaling pathway via JAK-STAT
GO_0010629	Biological process	negative regulation of gene expression
GO_0009968	Biological process	negative regulation of signal transduction
GO_0034244	Biological process	negative regulation of transcription elongation by RNA polymerase II
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_1990000	Biological process	amyloid fibril formation
GO_0045597	Biological process	positive regulation of cell differentiation
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0050821	Biological process	protein stabilization
GO_0006508	Biological process	proteolysis
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0010507	Biological process	negative regulation of autophagy
GO_0000902	Biological process	cell morphogenesis
GO_1904262	Biological process	negative regulation of TORC1 signaling
GO_1900037	Biological process	regulation of cellular response to hypoxia
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0071456	Biological process	cellular response to hypoxia
GO_0005886	Cellular component	plasma membrane
GO_0005739	Cellular component	mitochondrion
GO_0005654	Cellular component	nucleoplasm
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0043232	Cellular component	intracellular non-membrane-bounded organelle
GO_0005634	Cellular component	nucleus
GO_1990756	Molecular function	ubiquitin-like ligase-substrate adaptor activity
GO_0019899	Molecular function	enzyme binding
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0060090	Molecular function	molecular adaptor activity
GO_0003711	Molecular function	transcription elongation factor activity
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	VHL
Protein name	von Hippel-Lindau tumor suppressor von-Hippel Lindau tumor supressor isoform 1 VHL protein von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) VHL von Hippel-Lindau tumor suppressor isoform 1 (von Hippel-Lindau tumor suppressor, isoform CRA_d) von Hippel-Lindau tumor suppressor isoform 2
Synonyms	hCG_1994953
Description	FUNCTION: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex . Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions . Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases . Ubiquitinates, in an oxygen-responsive manner, ADRB2 . Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR . .
Accessions	A0A8Q3WL21 Q9UMS7 ENST00000256474.3 [P40337-1] ENST00000696153.1 P40337 A0A8Q3SIA6 A0A0S2Z4K1 A0A024R2F2 ENST00000345392.2 [P40337-2] ENST00000696142.1 I6RYK4 J9Z661 ENST00000696143.1 Q9UMS8

VHL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review