DDRGK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901800Biological processpositive regulation of proteasomal protein catabolic process
GO_1902808Biological processpositive regulation of cell cycle G1/S phase transition
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0010629Biological processnegative regulation of gene expression
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_1905552Biological processpositive regulation of protein localization to endoplasmic reticulum
GO_0033146Biological processregulation of intracellular estrogen receptor signaling pathway
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_1903895Biological processnegative regulation of IRE1-mediated unfolded protein response
GO_0010628Biological processpositive regulation of gene expression
GO_0140501Biological processpositive regulation of reticulophagy
GO_1990592Biological processprotein K69-linked ufmylation
GO_0072344Biological processrescue of stalled ribosome
GO_1905050Biological processpositive regulation of metallopeptidase activity
GO_0070972Biological processprotein localization to endoplasmic reticulum
GO_0032790Biological processribosome disassembly
GO_0071569Biological processprotein ufmylation
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030335Biological processpositive regulation of cell migration
GO_1903898Biological processnegative regulation of PERK-mediated unfolded protein response
GO_1903721Biological processpositive regulation of I-kappaB phosphorylation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0061709Biological processreticulophagy
GO_1905636Biological processpositive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO_1900100Biological processpositive regulation of plasma cell differentiation
GO_0051216Biological processcartilage development
GO_0031647Biological processregulation of protein stability
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0141185Molecular functionUFM1-modified protein reader activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0005515Molecular functionprotein binding
GO_0044389Molecular functionubiquitin-like protein ligase binding

IV. Literature review

[source]
Gene nameDDRGK1
Protein nameDDRGK domain-containing protein 1 (Dashurin) (UFM1-binding and PCI domain-containing protein 1)
DDRGK domain-containing protein 1
SynonymsC20orf116
UFBP1
DescriptionFUNCTION: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy) . In response to endoplasmic reticulum stress, promotes recruitment of the E3 UFM1-protein ligase UFL1 to the endoplasmic reticulum membrane: in turn, UFL1 mediates ufmylation of proteins such as RPN1 and RPL26/uL24, promoting reticulophagy of endoplasmic reticulum sheets . Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability . Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis or inflammatory response (By similarity). Required for TRIP4 ufmylation, thereby regulating nuclear receptors-mediated. transcription . May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B . Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator . .

AccessionsQ96HY6
ENST00000354488.8 [Q96HY6-1]
ENST00000380201.2
A0A0A0MRX2