SPI1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090402Biological processoncogene-induced cell senescence
GO_1905453Biological processregulation of myeloid progenitor cell differentiation
GO_0010629Biological processnegative regulation of gene expression
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0002572Biological processpro-T cell differentiation
GO_0036462Biological processTRAIL-activated apoptotic signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045579Biological processpositive regulation of B cell differentiation
GO_1900745Biological processpositive regulation of p38MAPK cascade
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0120186Biological processnegative regulation of protein localization to chromatin
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0070102Biological processinterleukin-6-mediated signaling pathway
GO_1904178Biological processnegative regulation of adipose tissue development
GO_0030154Biological processcell differentiation
GO_0045646Biological processregulation of erythrocyte differentiation
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0002573Biological processmyeloid leukocyte differentiation
GO_1905036Biological processpositive regulation of antifungal innate immune response
GO_0006355Biological processregulation of DNA-templated transcription
GO_0043314Biological processnegative regulation of neutrophil degranulation
GO_0098508Biological processendothelial to hematopoietic transition
GO_0002357Biological processdefense response to tumor cell
GO_0051090Biological processregulation of DNA-binding transcription factor activity
GO_1904238Biological processpericyte cell differentiation
GO_1904151Biological processpositive regulation of microglial cell mediated cytotoxicity
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0097677Molecular functionSTAT family protein binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0051525Molecular functionNFAT protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0003723Molecular functionRNA binding
GO_0001216Molecular functionDNA-binding transcription activator activity
GO_0140311Molecular functionprotein sequestering activity
GO_0001217Molecular functionDNA-binding transcription repressor activity
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameSPI1
Protein nameSpi-1 proto-oncogene
Transcription factor PU.1 (31 kDa-transforming protein)
Synonyms
DescriptionFUNCTION: Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions . Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition . Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box . In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity). .

AccessionsENST00000533030.1
ENST00000227163.8 [P17947-2]
P17947
F5H3K6
ENST00000533968.1
ENST00000378538.8 [P17947-1]
F5GZ94