TIPARP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
mast cell	15 studies	30% ± 14%	Explore
endothelial cell	14 studies	25% ± 5%	Explore
fibroblast	14 studies	25% ± 8%	Explore
natural killer cell	13 studies	22% ± 6%	Explore
smooth muscle cell	13 studies	29% ± 13%	Explore
conventional dendritic cell	12 studies	29% ± 11%	Explore
macrophage	11 studies	23% ± 8%	Explore
basal cell	11 studies	26% ± 8%	Explore
classical monocyte	10 studies	25% ± 9%	Explore
pericyte	9 studies	31% ± 13%	Explore
epithelial cell	8 studies	35% ± 18%	Explore
astrocyte	8 studies	25% ± 8%	Explore
type II pneumocyte	7 studies	24% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	22% ± 8%	Explore
CD4-positive, alpha-beta T cell	7 studies	19% ± 2%	Explore
CD8-positive, alpha-beta T cell	7 studies	19% ± 3%	Explore
secretory cell	7 studies	21% ± 4%	Explore
T cell	6 studies	31% ± 12%	Explore
non-classical monocyte	6 studies	20% ± 4%	Explore
mature NK T cell	6 studies	19% ± 6%	Explore
myeloid cell	6 studies	24% ± 8%	Explore
ciliated cell	6 studies	26% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	27% ± 5%	Explore
gamma-delta T cell	6 studies	29% ± 10%	Explore
endothelial cell of vascular tree	6 studies	26% ± 11%	Explore
dendritic cell	5 studies	27% ± 9%	Explore
monocyte	5 studies	24% ± 7%	Explore
type I pneumocyte	5 studies	26% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	25% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 6%	Explore
mucosal invariant T cell	5 studies	27% ± 9%	Explore
squamous epithelial cell	4 studies	32% ± 21%	Explore
regulatory T cell	4 studies	19% ± 5%	Explore
connective tissue cell	4 studies	26% ± 15%	Explore
lymphocyte	3 studies	27% ± 10%	Explore
myofibroblast cell	3 studies	31% ± 13%	Explore
CD4-positive helper T cell	3 studies	31% ± 8%	Explore
innate lymphoid cell	3 studies	37% ± 4%	Explore
adipocyte	3 studies	23% ± 5%	Explore
granulocyte	3 studies	27% ± 7%	Explore
leukocyte	3 studies	29% ± 7%	Explore
alveolar macrophage	3 studies	21% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	36% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	5 studies	24% ± 6%	Explore
peripheral blood	5 studies	21% ± 3%	Explore
uterus	4 studies	32% ± 11%	Explore
breast	3 studies	20% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	99%	3244.36	1433 / 1445	100%	41.28	183 / 183
lung	99%	3541.55	574 / 578	99%	46.18	1146 / 1155
prostate	100%	2656.09	244 / 245	98%	37.10	491 / 502
breast	100%	3108.95	459 / 459	97%	31.90	1084 / 1118
bladder	100%	2413.71	21 / 21	96%	29.04	485 / 504
thymus	99%	2562.14	644 / 653	96%	71.50	583 / 605
uterus	100%	3324.19	170 / 170	95%	34.14	434 / 459
intestine	99%	2260.78	958 / 966	95%	22.02	500 / 527
ovary	100%	6455.82	180 / 180	94%	17.20	403 / 430
brain	87%	1410.01	2309 / 2642	99%	48.13	698 / 705
skin	100%	5862.40	1808 / 1809	84%	15.00	398 / 472
stomach	87%	1983.31	311 / 359	96%	20.72	274 / 286
kidney	81%	1450.74	72 / 89	90%	45.11	810 / 901
adrenal gland	93%	2898.34	241 / 258	67%	16.08	153 / 230
liver	81%	1179.85	182 / 226	78%	12.52	318 / 406
pancreas	54%	593.93	176 / 328	97%	31.39	172 / 178
ureter	0%	0	0 / 0	100%	11.18	1 / 1
adipose	100%	4679.18	1200 / 1204	0%	0	0 / 0
blood vessel	99%	4036.04	1319 / 1335	0%	0	0 / 0
spleen	98%	1407.41	235 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	42.25	42 / 45
peripheral blood	92%	2858.17	856 / 929	0%	0	0 / 0
heart	91%	2924.29	782 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	86%	15.18	25 / 29
muscle	80%	1623.18	646 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	34%	5.93	27 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030097	Biological process	hemopoiesis
GO_0009791	Biological process	post-embryonic development
GO_0008209	Biological process	androgen metabolic process
GO_0010629	Biological process	negative regulation of gene expression
GO_0001570	Biological process	vasculogenesis
GO_0001822	Biological process	kidney development
GO_0048008	Biological process	platelet-derived growth factor receptor signaling pathway
GO_0045732	Biological process	positive regulation of protein catabolic process
GO_0060021	Biological process	roof of mouth development
GO_1904612	Biological process	response to 2,3,7,8-tetrachlorodibenzodioxine
GO_0008210	Biological process	estrogen metabolic process
GO_0060325	Biological process	face morphogenesis
GO_0008585	Biological process	female gonad development
GO_0071407	Biological process	cellular response to organic cyclic compound
GO_0048745	Biological process	smooth muscle tissue development
GO_0048705	Biological process	skeletal system morphogenesis
GO_0005634	Cellular component	nucleus
GO_0016779	Molecular function	nucleotidyltransferase activity
GO_0003950	Molecular function	NAD+ ADP-ribosyltransferase activity
GO_0140803	Molecular function	NAD+- protein-cysteine ADP-ribosyltransferase activity
GO_0000987	Molecular function	cis-regulatory region sequence-specific DNA binding
GO_0046872	Molecular function	metal ion binding
GO_1990404	Molecular function	NAD+-protein ADP-ribosyltransferase activity

IV. Literature review

[source]

Gene name	TIPARP
Protein name	TCDD inducible poly(ADP-ribose) polymerase (TCDD-inducible poly(ADP-ribose) polymerase, isoform CRA_b) TIPARP protein Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) TCDD inducible poly(ADP-ribose) polymerase (TCDD-inducible poly(ADP-ribose) polymerase, isoform CRA_c) Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) (TCDD-inducible poly [ADP-ribose] polymerase)
Synonyms	hCG_27716 PARP7
Description	FUNCTION: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins . Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR . .
Accessions	Q7Z3E1 G5E9W1 ENST00000486483.5 Q05BQ2 C9JXM5 ENST00000542783.5 H7C5K7 ENST00000481853.5 ENST00000473702.5 ENST00000495891.1 ENST00000461166.5 ENST00000295924.12

TIPARP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review