Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 12503.73 | 180 / 180 | 100% | 130.72 | 429 / 430 |
| esophagus | 100% | 23735.18 | 1442 / 1445 | 99% | 75.26 | 181 / 183 |
| uterus | 100% | 52060.53 | 170 / 170 | 98% | 76.52 | 450 / 459 |
| skin | 100% | 19849.13 | 1808 / 1809 | 98% | 83.58 | 462 / 472 |
| lung | 100% | 17154.49 | 576 / 578 | 97% | 69.18 | 1122 / 1155 |
| breast | 100% | 12881.59 | 457 / 459 | 97% | 63.89 | 1085 / 1118 |
| thymus | 99% | 7966.32 | 647 / 653 | 97% | 46.11 | 585 / 605 |
| adrenal gland | 100% | 12499.21 | 258 / 258 | 95% | 65.23 | 219 / 230 |
| brain | 89% | 6859.47 | 2348 / 2642 | 100% | 104.09 | 703 / 705 |
| bladder | 100% | 26151.71 | 21 / 21 | 77% | 37.00 | 390 / 504 |
| prostate | 98% | 11878.72 | 241 / 245 | 78% | 31.78 | 392 / 502 |
| intestine | 96% | 38963.86 | 925 / 966 | 67% | 24.18 | 355 / 527 |
| kidney | 70% | 3337.38 | 62 / 89 | 93% | 53.10 | 836 / 901 |
| stomach | 61% | 12145.36 | 218 / 359 | 80% | 41.33 | 230 / 286 |
| pancreas | 30% | 1754.27 | 100 / 328 | 97% | 61.83 | 173 / 178 |
| liver | 52% | 3692.75 | 118 / 226 | 55% | 17.01 | 222 / 406 |
| adipose | 100% | 16759.70 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 19053.09 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 57.55 | 1 / 1 |
| eye | 0% | 0 | 0 / 0 | 98% | 55.39 | 78 / 80 |
| heart | 97% | 11799.18 | 836 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 78.35 | 43 / 45 |
| spleen | 94% | 5156.94 | 226 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 66% | 18.10 | 19 / 29 |
| peripheral blood | 63% | 4322.38 | 583 / 929 | 0% | 0 | 0 / 0 |
| muscle | 19% | 807.35 | 156 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0098736 | Biological process | negative regulation of the force of heart contraction |
| GO_0051480 | Biological process | regulation of cytosolic calcium ion concentration |
| GO_1903243 | Biological process | negative regulation of cardiac muscle hypertrophy in response to stress |
| GO_0007283 | Biological process | spermatogenesis |
| GO_0021766 | Biological process | hippocampus development |
| GO_0097553 | Biological process | calcium ion transmembrane import into cytosol |
| GO_0070885 | Biological process | negative regulation of calcineurin-NFAT signaling cascade |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_1902548 | Biological process | negative regulation of cellular response to vascular endothelial growth factor stimulus |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0038060 | Biological process | nitric oxide-cGMP-mediated signaling |
| GO_0051599 | Biological process | response to hydrostatic pressure |
| GO_0150104 | Biological process | transport across blood-brain barrier |
| GO_0003407 | Biological process | neural retina development |
| GO_0034220 | Biological process | monoatomic ion transmembrane transport |
| GO_0051001 | Biological process | negative regulation of nitric-oxide synthase activity |
| GO_0098703 | Biological process | calcium ion import across plasma membrane |
| GO_1902806 | Biological process | regulation of cell cycle G1/S phase transition |
| GO_0071872 | Biological process | cellular response to epinephrine stimulus |
| GO_0045019 | Biological process | negative regulation of nitric oxide biosynthetic process |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0043537 | Biological process | negative regulation of blood vessel endothelial cell migration |
| GO_0016525 | Biological process | negative regulation of angiogenesis |
| GO_1902083 | Biological process | negative regulation of peptidyl-cysteine S-nitrosylation |
| GO_1903078 | Biological process | positive regulation of protein localization to plasma membrane |
| GO_0014832 | Biological process | urinary bladder smooth muscle contraction |
| GO_0030317 | Biological process | flagellated sperm motility |
| GO_1903249 | Biological process | negative regulation of citrulline biosynthetic process |
| GO_0071878 | Biological process | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway |
| GO_1905145 | Biological process | cellular response to acetylcholine |
| GO_1903779 | Biological process | regulation of cardiac conduction |
| GO_1900082 | Biological process | negative regulation of arginine catabolic process |
| GO_1902305 | Biological process | regulation of sodium ion transmembrane transport |
| GO_1901660 | Biological process | calcium ion export |
| GO_0070588 | Biological process | calcium ion transmembrane transport |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0036126 | Cellular component | sperm flagellum |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0045121 | Cellular component | membrane raft |
| GO_0016020 | Cellular component | membrane |
| GO_0030018 | Cellular component | Z disc |
| GO_0048787 | Cellular component | presynaptic active zone membrane |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0030315 | Cellular component | T-tubule |
| GO_0097228 | Cellular component | sperm principal piece |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0005901 | Cellular component | caveola |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0015085 | Molecular function | calcium ion transmembrane transporter activity |
| GO_0005388 | Molecular function | P-type calcium transporter activity |
| GO_0050998 | Molecular function | nitric-oxide synthase binding |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0030165 | Molecular function | PDZ domain binding |
| GO_0097110 | Molecular function | scaffold protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0036487 | Molecular function | nitric-oxide synthase inhibitor activity |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0017080 | Molecular function | sodium channel regulator activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| GO_0030346 | Molecular function | protein phosphatase 2B binding |
| Gene name | ATP2B4 |
| Protein name | Calcium-transporting ATPase (EC 7.2.2.10) ATPase plasma membrane Ca2+ transporting 4 PMCA4b PMCA4x Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) |
| Synonyms | MXRA1 ATP2B2 |
| Description | FUNCTION: Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell . By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). . FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of calcium. . |
| Accessions | A1X4Q2 ENST00000458092.5 ENST00000705901.1 [P23634-3] P23634 ENST00000357681.10 [P23634-6] ENST00000484746.1 H0YDG5 A1X4Q1 H7BY13 A7E2D8 ENST00000341360.7 [P23634-2] H7BZS8 ENST00000356729.5 |
