OCLN | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
type I pneumocyte	12 studies	31% ± 12%	Explore
epithelial cell	11 studies	34% ± 15%	Explore
ciliated cell	7 studies	28% ± 12%	Explore
type II pneumocyte	6 studies	27% ± 9%	Explore
endothelial cell	6 studies	22% ± 5%	Explore
club cell	5 studies	28% ± 15%	Explore
hepatocyte	4 studies	34% ± 18%	Explore
secretory cell	4 studies	25% ± 7%	Explore
goblet cell	4 studies	26% ± 10%	Explore
kidney loop of Henle epithelial cell	3 studies	22% ± 5%	Explore
cholangiocyte	3 studies	52% ± 15%	Explore
luminal cell of prostate epithelium	3 studies	22% ± 5%	Explore
pancreatic ductal cell	3 studies	54% ± 26%	Explore
intestinal crypt stem cell	3 studies	17% ± 2%	Explore
basal cell	3 studies	23% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	3 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	1078.50	328 / 328	88%	9.75	157 / 178
thymus	100%	1734.78	652 / 653	85%	20.88	514 / 605
liver	100%	653.34	226 / 226	81%	11.75	330 / 406
lung	99%	1179.90	575 / 578	82%	13.07	942 / 1155
stomach	76%	938.56	274 / 359	97%	17.19	277 / 286
prostate	74%	193.08	182 / 245	88%	9.94	441 / 502
kidney	98%	483.45	87 / 89	58%	6.14	519 / 901
breast	60%	242.73	277 / 459	90%	12.77	1010 / 1118
intestine	53%	427.78	508 / 966	97%	13.61	512 / 527
esophagus	44%	391.56	635 / 1445	79%	14.84	145 / 183
bladder	43%	329.90	9 / 21	72%	7.71	365 / 504
ovary	18%	41.93	32 / 180	93%	8.55	398 / 430
uterus	25%	72.79	42 / 170	62%	5.47	285 / 459
skin	73%	716.74	1317 / 1809	2%	0.10	9 / 472
brain	61%	130.74	1606 / 2642	2%	0.08	14 / 705
tonsil	0%	0	0 / 0	44%	3.26	20 / 45
spleen	16%	35.09	39 / 241	0%	0	0 / 0
peripheral blood	16%	46.23	147 / 929	0%	0	0 / 0
adipose	14%	27.08	163 / 1204	0%	0	0 / 0
blood vessel	8%	14.21	105 / 1335	0%	0	0 / 0
adrenal gland	5%	9.10	14 / 258	0%	0	0 / 230
heart	3%	3.95	23 / 861	0%	0	0 / 0
muscle	0%	0.14	1 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0046326	Biological process	positive regulation of glucose import
GO_0010629	Biological process	negative regulation of gene expression
GO_0010628	Biological process	positive regulation of gene expression
GO_0010592	Biological process	positive regulation of lamellipodium assembly
GO_0031116	Biological process	positive regulation of microtubule polymerization
GO_0045216	Biological process	cell-cell junction organization
GO_0065003	Biological process	protein-containing complex assembly
GO_0001933	Biological process	negative regulation of protein phosphorylation
GO_0070830	Biological process	bicellular tight junction assembly
GO_1902463	Biological process	protein localization to cell leading edge
GO_0035633	Biological process	maintenance of blood-brain barrier
GO_1905605	Biological process	positive regulation of blood-brain barrier permeability
GO_0010827	Biological process	regulation of glucose transmembrane transport
GO_0090303	Biological process	positive regulation of wound healing
GO_0016324	Cellular component	apical plasma membrane
GO_0070160	Cellular component	tight junction
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0030139	Cellular component	endocytic vesicle
GO_0032991	Cellular component	protein-containing complex
GO_0031252	Cellular component	cell leading edge
GO_0005911	Cellular component	cell-cell junction
GO_0005923	Cellular component	bicellular tight junction
GO_0030054	Cellular component	cell junction
GO_0016327	Cellular component	apicolateral plasma membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0019904	Molecular function	protein domain specific binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	OCLN
Protein name	Occludin
Synonyms
Description	FUNCTION: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. .; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. . FUNCTION: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. .
Accessions	ENST00000355237.6 [Q16625-1] A0A0G2JPF2 ENST00000681588.1 ENST00000620655.1 ENST00000681041.1 [Q16625-1] ENST00000615870.4 ENST00000617110.4 A0A0G2JMZ8 A0A7P0TB95 ENST00000680027.1 [Q16625-1] ENST00000681586.1 [Q16625-1] ENST00000680784.1 [Q16625-2] ENST00000613193.4 Q16625 ENST00000680496.1 [Q16625-2] ENST00000538151.2 [Q16625-4] ENST00000681895.1 ENST00000680098.1 A0A7P0T9T6 ENST00000396442.7 [Q16625-1]

OCLN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review