DICER1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035196Biological processmiRNA processing
GO_0010629Biological processnegative regulation of gene expression
GO_0021675Biological processnerve development
GO_0016078Biological processtRNA decay
GO_0014040Biological processpositive regulation of Schwann cell differentiation
GO_0010626Biological processnegative regulation of Schwann cell proliferation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0031054Biological processpre-miRNA processing
GO_0048812Biological processneuron projection morphogenesis
GO_0098795Biological processglobal gene silencing by mRNA cleavage
GO_0032290Biological processperipheral nervous system myelin formation
GO_0030422Biological processsiRNA processing
GO_0070922Biological processRISC complex assembly
GO_0031643Biological processpositive regulation of myelination
GO_0006309Biological processapoptotic DNA fragmentation
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_0010586Biological processmiRNA metabolic process
GO_0070578Cellular componentRISC-loading complex
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0016442Cellular componentRISC complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0004521Molecular functionRNA endonuclease activity
GO_0004386Molecular functionhelicase activity
GO_0004525Molecular functionribonuclease III activity
GO_0019904Molecular functionprotein domain specific binding
GO_0035197Molecular functionsiRNA binding
GO_0070883Molecular functionpre-miRNA binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0004530Molecular functiondeoxyribonuclease I activity
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameDICER1
Protein nameEndoribonuclease Dicer (EC 3.1.26.3)
Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI)
ribonuclease III (EC 3.1.26.3)
Dicer 1, ribonuclease III
Endoribonuclease Dicer
DICER variant 2 (DICER variant 3) (Endoribonuclease Dicer)
SynonymsHERNA
DICER
KIAA0928
DescriptionFUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. .

FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. .

FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. .

FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. .

FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. .

FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. .

FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. .

AccessionsENST00000526495.6 [Q9UPY3-1]
ENST00000696740.1
Q5D0K5
F6SZ09
ENST00000531162.6
Q9UPY3
ENST00000696733.1
ENST00000696924.1
ENST00000393063.6 [Q9UPY3-1]
ENST00000531162.7 [Q9UPY3-1]
A0A6Q8PHG6
A0A8Q3WLH6
A0A7I2YBM0
ENST00000674628.1
ENST00000343455.8 [Q9UPY3-1]
A0A8Q3WLH8
ENST00000556045.6
ENST00000696736.1
A0A6Q8PH99
ENST00000675995.1
A0A6Q8PFV4
H0YJZ6
ENST00000541352.5 [Q9UPY3-2]
A0A8Q3WLJ5
ENST00000696737.1
ENST00000696923.1
A0A8Q3SJI0
ENST00000696734.1
ENST00000527414.5 [Q9UPY3-1]
ENST00000532939.3
ENST00000674628.2 [Q9UPY3-1]
ENST00000529720.2 [Q9UPY3-1]
ENST00000529720.1
A0A8F5XQU3
ENST00000675540.2