Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 26 studies | 30% ± 13% | |
macrophage | 22 studies | 28% ± 13% | |
classical monocyte | 17 studies | 26% ± 11% | |
oligodendrocyte | 15 studies | 54% ± 20% | |
astrocyte | 15 studies | 36% ± 17% | |
non-classical monocyte | 14 studies | 27% ± 10% | |
fibroblast | 13 studies | 28% ± 12% | |
monocyte | 12 studies | 27% ± 9% | |
pericyte | 11 studies | 24% ± 10% | |
microglial cell | 10 studies | 33% ± 12% | |
smooth muscle cell | 9 studies | 24% ± 7% | |
neuron | 9 studies | 36% ± 17% | |
endothelial cell of artery | 9 studies | 19% ± 4% | |
glutamatergic neuron | 9 studies | 44% ± 26% | |
oligodendrocyte precursor cell | 9 studies | 40% ± 17% | |
epithelial cell | 9 studies | 35% ± 14% | |
GABAergic neuron | 8 studies | 44% ± 23% | |
type I pneumocyte | 7 studies | 22% ± 7% | |
myeloid cell | 7 studies | 32% ± 11% | |
basal cell | 7 studies | 28% ± 13% | |
ciliated cell | 7 studies | 25% ± 8% | |
adipocyte | 7 studies | 24% ± 5% | |
endothelial cell of lymphatic vessel | 6 studies | 27% ± 9% | |
B cell | 6 studies | 22% ± 4% | |
capillary endothelial cell | 6 studies | 19% ± 4% | |
amacrine cell | 6 studies | 29% ± 11% | |
interneuron | 6 studies | 44% ± 24% | |
club cell | 6 studies | 22% ± 6% | |
retina horizontal cell | 6 studies | 22% ± 10% | |
retinal rod cell | 6 studies | 22% ± 6% | |
retinal bipolar neuron | 5 studies | 28% ± 6% | |
retinal cone cell | 5 studies | 24% ± 5% | |
dendritic cell | 5 studies | 29% ± 11% | |
mast cell | 5 studies | 22% ± 6% | |
secretory cell | 4 studies | 19% ± 3% | |
glial cell | 4 studies | 28% ± 4% | |
granule cell | 4 studies | 24% ± 4% | |
retinal ganglion cell | 4 studies | 30% ± 8% | |
mononuclear phagocyte | 4 studies | 30% ± 6% | |
lymphocyte | 4 studies | 25% ± 6% | |
hepatocyte | 4 studies | 43% ± 21% | |
type II pneumocyte | 4 studies | 24% ± 6% | |
natural killer cell | 4 studies | 17% ± 1% | |
goblet cell | 4 studies | 31% ± 21% | |
ionocyte | 3 studies | 23% ± 4% | |
pancreatic A cell | 3 studies | 31% ± 14% | |
hematopoietic precursor cell | 3 studies | 27% ± 7% | |
abnormal cell | 3 studies | 30% ± 11% | |
vein endothelial cell | 3 studies | 36% ± 21% | |
OFF-bipolar cell | 3 studies | 30% ± 9% | |
ON-bipolar cell | 3 studies | 38% ± 9% | |
glycinergic amacrine cell | 3 studies | 26% ± 9% | |
rod bipolar cell | 3 studies | 44% ± 14% | |
respiratory goblet cell | 3 studies | 24% ± 2% | |
luminal hormone-sensing cell of mammary gland | 3 studies | 23% ± 9% | |
connective tissue cell | 3 studies | 22% ± 8% | |
enteroendocrine cell | 3 studies | 21% ± 5% | |
leukocyte | 3 studies | 23% ± 2% | |
alveolar macrophage | 3 studies | 35% ± 13% | |
Schwann cell | 3 studies | 35% ± 19% | |
transit amplifying cell | 3 studies | 34% ± 22% | |
mesothelial cell | 3 studies | 27% ± 3% | |
kidney loop of Henle epithelial cell | 3 studies | 20% ± 5% | |
mucus secreting cell | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 6528.29 | 1445 / 1445 | 100% | 29.41 | 183 / 183 |
lung | 100% | 7312.29 | 578 / 578 | 100% | 19.07 | 1151 / 1155 |
prostate | 100% | 6487.31 | 245 / 245 | 99% | 21.99 | 499 / 502 |
breast | 100% | 7631.29 | 459 / 459 | 99% | 27.41 | 1110 / 1118 |
brain | 100% | 4110.89 | 2630 / 2642 | 100% | 20.54 | 702 / 705 |
pancreas | 100% | 3483.51 | 327 / 328 | 99% | 16.42 | 176 / 178 |
bladder | 100% | 6247.43 | 21 / 21 | 98% | 17.08 | 496 / 504 |
thymus | 100% | 7756.48 | 653 / 653 | 98% | 15.85 | 595 / 605 |
uterus | 100% | 7224.01 | 170 / 170 | 98% | 19.84 | 451 / 459 |
stomach | 100% | 4009.32 | 359 / 359 | 97% | 15.95 | 277 / 286 |
ovary | 100% | 6679.79 | 180 / 180 | 96% | 11.27 | 413 / 430 |
intestine | 100% | 6000.46 | 966 / 966 | 96% | 14.16 | 504 / 527 |
adrenal gland | 100% | 3715.22 | 258 / 258 | 95% | 14.58 | 218 / 230 |
kidney | 100% | 3886.52 | 89 / 89 | 94% | 14.34 | 849 / 901 |
skin | 100% | 5528.91 | 1808 / 1809 | 93% | 16.43 | 440 / 472 |
liver | 100% | 2818.75 | 226 / 226 | 81% | 8.00 | 330 / 406 |
adipose | 100% | 7013.51 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 6126.05 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 5363.04 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 5964.88 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.43 | 1 / 1 |
heart | 98% | 3000.68 | 844 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 15.85 | 28 / 29 |
tonsil | 0% | 0 | 0 / 0 | 96% | 21.16 | 43 / 45 |
peripheral blood | 87% | 4927.97 | 806 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 54% | 4.99 | 43 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0035196 | Biological process | miRNA processing |
GO_0010629 | Biological process | negative regulation of gene expression |
GO_0021675 | Biological process | nerve development |
GO_0016078 | Biological process | tRNA decay |
GO_0014040 | Biological process | positive regulation of Schwann cell differentiation |
GO_0010626 | Biological process | negative regulation of Schwann cell proliferation |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0031054 | Biological process | pre-miRNA processing |
GO_0048812 | Biological process | neuron projection morphogenesis |
GO_0098795 | Biological process | global gene silencing by mRNA cleavage |
GO_0032290 | Biological process | peripheral nervous system myelin formation |
GO_0030422 | Biological process | siRNA processing |
GO_0070922 | Biological process | RISC complex assembly |
GO_0031643 | Biological process | positive regulation of myelination |
GO_0006309 | Biological process | apoptotic DNA fragmentation |
GO_0032720 | Biological process | negative regulation of tumor necrosis factor production |
GO_0010804 | Biological process | negative regulation of tumor necrosis factor-mediated signaling pathway |
GO_0010586 | Biological process | miRNA metabolic process |
GO_0070578 | Cellular component | RISC-loading complex |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0016442 | Cellular component | RISC complex |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0004521 | Molecular function | RNA endonuclease activity |
GO_0004386 | Molecular function | helicase activity |
GO_0004525 | Molecular function | ribonuclease III activity |
GO_0019904 | Molecular function | protein domain specific binding |
GO_0035197 | Molecular function | siRNA binding |
GO_0070883 | Molecular function | pre-miRNA binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0003723 | Molecular function | RNA binding |
GO_0005515 | Molecular function | protein binding |
GO_0004530 | Molecular function | deoxyribonuclease I activity |
GO_0003725 | Molecular function | double-stranded RNA binding |
Gene name | DICER1 |
Protein name | Endoribonuclease Dicer (EC 3.1.26.3) Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) ribonuclease III (EC 3.1.26.3) Dicer 1, ribonuclease III Endoribonuclease Dicer DICER variant 2 (DICER variant 3) (Endoribonuclease Dicer) |
Synonyms | HERNA DICER KIAA0928 |
Description | FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. . FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. . FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. . FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. . FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. . FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. . FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. . |
Accessions | ENST00000526495.6 [Q9UPY3-1] ENST00000696740.1 Q5D0K5 F6SZ09 ENST00000531162.6 Q9UPY3 ENST00000696733.1 ENST00000696924.1 ENST00000393063.6 [Q9UPY3-1] ENST00000531162.7 [Q9UPY3-1] A0A6Q8PHG6 A0A8Q3WLH6 A0A7I2YBM0 ENST00000674628.1 ENST00000343455.8 [Q9UPY3-1] A0A8Q3WLH8 ENST00000556045.6 ENST00000696736.1 A0A6Q8PH99 ENST00000675995.1 A0A6Q8PFV4 H0YJZ6 ENST00000541352.5 [Q9UPY3-2] A0A8Q3WLJ5 ENST00000696737.1 ENST00000696923.1 A0A8Q3SJI0 ENST00000696734.1 ENST00000527414.5 [Q9UPY3-1] ENST00000532939.3 ENST00000674628.2 [Q9UPY3-1] ENST00000529720.2 [Q9UPY3-1] ENST00000529720.1 A0A8F5XQU3 ENST00000675540.2 |