RBL2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	31 studies	28% ± 10%	Explore
CD8-positive, alpha-beta T cell	29 studies	29% ± 9%	Explore
natural killer cell	28 studies	26% ± 7%	Explore
T cell	24 studies	29% ± 10%	Explore
mature NK T cell	17 studies	26% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	32% ± 11%	Explore
endothelial cell	16 studies	26% ± 10%	Explore
regulatory T cell	16 studies	28% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	29% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	28% ± 6%	Explore
gamma-delta T cell	15 studies	29% ± 7%	Explore
mucosal invariant T cell	14 studies	38% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	36% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	32% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	33% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	30% ± 8%	Explore
B cell	10 studies	19% ± 3%	Explore
naive B cell	9 studies	20% ± 2%	Explore
fibroblast	9 studies	23% ± 9%	Explore
oligodendrocyte	9 studies	32% ± 10%	Explore
GABAergic neuron	8 studies	34% ± 19%	Explore
oligodendrocyte precursor cell	8 studies	29% ± 14%	Explore
ciliated cell	7 studies	27% ± 9%	Explore
astrocyte	7 studies	35% ± 11%	Explore
type I pneumocyte	6 studies	20% ± 5%	Explore
plasmacytoid dendritic cell	6 studies	20% ± 4%	Explore
classical monocyte	6 studies	21% ± 5%	Explore
glutamatergic neuron	6 studies	46% ± 24%	Explore
interneuron	6 studies	36% ± 22%	Explore
microglial cell	6 studies	24% ± 5%	Explore
memory B cell	6 studies	18% ± 2%	Explore
T follicular helper cell	6 studies	28% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	30% ± 10%	Explore
macrophage	6 studies	24% ± 7%	Explore
type II pneumocyte	6 studies	26% ± 7%	Explore
exhausted T cell	5 studies	32% ± 5%	Explore
lymphocyte	5 studies	40% ± 17%	Explore
epithelial cell	5 studies	34% ± 14%	Explore
adipocyte	5 studies	28% ± 8%	Explore
innate lymphoid cell	5 studies	24% ± 7%	Explore
endothelial cell of lymphatic vessel	5 studies	24% ± 5%	Explore
club cell	5 studies	21% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	31% ± 5%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	23% ± 5%	Explore
neuron	4 studies	28% ± 14%	Explore
basal cell	4 studies	29% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	29% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	27% ± 9%	Explore
monocyte	4 studies	20% ± 2%	Explore
pericyte	4 studies	20% ± 5%	Explore
smooth muscle cell	4 studies	18% ± 2%	Explore
CD4-positive helper T cell	3 studies	24% ± 9%	Explore
ionocyte	3 studies	32% ± 4%	Explore
non-classical monocyte	3 studies	23% ± 6%	Explore
glial cell	3 studies	16% ± 1%	Explore
Mueller cell	3 studies	19% ± 2%	Explore
amacrine cell	3 studies	22% ± 3%	Explore
endothelial cell of vascular tree	3 studies	25% ± 9%	Explore
hepatocyte	3 studies	32% ± 5%	Explore
dendritic cell	3 studies	25% ± 9%	Explore
group 3 innate lymphoid cell	3 studies	36% ± 4%	Explore
goblet cell	3 studies	34% ± 21%	Explore
T-helper 17 cell	3 studies	27% ± 8%	Explore
mast cell	3 studies	20% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	32% ± 11%	Explore
double negative thymocyte	3 studies	30% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	26% ± 4%	Explore
brain	8 studies	40% ± 19%	Explore
lung	7 studies	17% ± 5%	Explore
liver	4 studies	24% ± 5%	Explore
eye	3 studies	27% ± 13%	Explore
kidney	3 studies	21% ± 3%	Explore
adipose	3 studies	22% ± 2%	Explore
lymph node	3 studies	20% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4916.17	1445 / 1445	100%	33.12	183 / 183
stomach	100%	5132.71	359 / 359	100%	26.22	285 / 286
lung	100%	5991.75	578 / 578	99%	30.58	1149 / 1155
intestine	100%	5591.86	966 / 966	99%	25.16	523 / 527
breast	100%	6293.57	459 / 459	98%	34.93	1095 / 1118
pancreas	100%	4522.79	328 / 328	97%	26.47	173 / 178
kidney	100%	3910.80	89 / 89	97%	32.90	875 / 901
thymus	100%	6810.17	653 / 653	97%	35.45	586 / 605
prostate	100%	6006.42	245 / 245	97%	40.50	486 / 502
bladder	100%	6563.29	21 / 21	96%	23.69	485 / 504
brain	97%	2896.64	2570 / 2642	99%	31.84	697 / 705
ovary	100%	6052.97	180 / 180	94%	16.90	404 / 430
uterus	100%	6268.98	170 / 170	94%	21.51	431 / 459
adrenal gland	100%	4386.42	258 / 258	92%	19.89	212 / 230
skin	100%	4970.11	1809 / 1809	91%	22.02	431 / 472
liver	99%	3271.76	223 / 226	82%	14.01	334 / 406
adipose	100%	6343.99	1204 / 1204	0%	0	0 / 0
blood vessel	100%	6988.57	1335 / 1335	0%	0	0 / 0
muscle	100%	3908.68	803 / 803	0%	0	0 / 0
spleen	100%	6160.77	241 / 241	0%	0	0 / 0
peripheral blood	97%	4836.84	904 / 929	0%	0	0 / 0
heart	94%	2832.73	813 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	22.33	42 / 45
lymph node	0%	0	0 / 0	93%	25.69	27 / 29
eye	0%	0	0 / 0	70%	11.01	56 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_2000134	Biological process	negative regulation of G1/S transition of mitotic cell cycle
GO_0030154	Biological process	cell differentiation
GO_0010629	Biological process	negative regulation of gene expression
GO_0043550	Biological process	regulation of lipid kinase activity
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0005730	Cellular component	nucleolus
GO_0070062	Cellular component	extracellular exosome
GO_0005694	Cellular component	chromosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0000785	Cellular component	chromatin
GO_0005667	Cellular component	transcription regulator complex
GO_1990841	Molecular function	promoter-specific chromatin binding
GO_0000977	Molecular function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	RBL2
Protein name	RB transcriptional corepressor like 2 Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)
Synonyms	RB2
Description	FUNCTION: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Accessions	F5H837 Q08999 J3KSF7 ENST00000262133.11 [Q08999-1] ENST00000544405.6 ENST00000567964.6

RBL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review