ROCK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006939Biological processsmooth muscle contraction
GO_0072659Biological processprotein localization to plasma membrane
GO_0010825Biological processpositive regulation of centrosome duplication
GO_1903347Biological processnegative regulation of bicellular tight junction assembly
GO_0071559Biological processresponse to transforming growth factor beta
GO_0070168Biological processnegative regulation of biomineral tissue development
GO_0030036Biological processactin cytoskeleton organization
GO_1902993Biological processpositive regulation of amyloid precursor protein catabolic process
GO_2000145Biological processregulation of cell motility
GO_0006468Biological processprotein phosphorylation
GO_0048511Biological processrhythmic process
GO_1900037Biological processregulation of cellular response to hypoxia
GO_0002931Biological processresponse to ischemia
GO_0010629Biological processnegative regulation of gene expression
GO_0035509Biological processnegative regulation of myosin-light-chain-phosphatase activity
GO_0010628Biological processpositive regulation of gene expression
GO_0000281Biological processmitotic cytokinesis
GO_1902966Biological processpositive regulation of protein localization to early endosome
GO_0032723Biological processpositive regulation of connective tissue growth factor production
GO_0042752Biological processregulation of circadian rhythm
GO_0044788Biological processmodulation by host of viral process
GO_1905145Biological processcellular response to acetylcholine
GO_0150033Biological processnegative regulation of protein localization to lysosome
GO_1905205Biological processpositive regulation of connective tissue replacement
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_0051298Biological processcentrosome duplication
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0003180Biological processaortic valve morphogenesis
GO_0061157Biological processmRNA destabilization
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0071394Biological processcellular response to testosterone stimulus
GO_0097746Biological processblood vessel diameter maintenance
GO_0031032Biological processactomyosin structure organization
GO_0048598Biological processembryonic morphogenesis
GO_1902004Biological processpositive regulation of amyloid-beta formation
GO_0051492Biological processregulation of stress fiber assembly
GO_0051893Biological processregulation of focal adhesion assembly
GO_0031644Biological processregulation of nervous system process
GO_1903140Biological processregulation of establishment of endothelial barrier
GO_0001837Biological processepithelial to mesenchymal transition
GO_2000114Biological processregulation of establishment of cell polarity
GO_0110061Biological processregulation of angiotensin-activated signaling pathway
GO_0010613Biological processpositive regulation of cardiac muscle hypertrophy
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_1901888Biological processregulation of cell junction assembly
GO_0045019Biological processnegative regulation of nitric oxide biosynthetic process
GO_0090271Biological processpositive regulation of fibroblast growth factor production
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0045616Biological processregulation of keratinocyte differentiation
GO_0016525Biological processnegative regulation of angiogenesis
GO_0030335Biological processpositive regulation of cell migration
GO_0007266Biological processRho protein signal transduction
GO_0030155Biological processregulation of cell adhesion
GO_0030866Biological processcortical actin cytoskeleton organization
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_1990776Biological processresponse to angiotensin
GO_0005856Cellular componentcytoskeleton
GO_0005634Cellular componentnucleus
GO_0005886Cellular componentplasma membrane
GO_0005813Cellular componentcentrosome
GO_0005737Cellular componentcytoplasm
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0005829Cellular componentcytosol
GO_0005524Molecular functionATP binding
GO_0048156Molecular functiontau protein binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0061133Molecular functionendopeptidase activator activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005198Molecular functionstructural molecule activity
GO_0002020Molecular functionprotease binding
GO_0050321Molecular functiontau-protein kinase activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0072518Molecular functionRho-dependent protein serine/threonine kinase activity

IV. Literature review

[source]
Gene nameROCK2
Protein nameRho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (p164 ROCK-2)
Rho-associated protein kinase (EC 2.7.11.1)
SynonymsKIAA0619
DescriptionFUNCTION: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. .

FUNCTION: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. .

AccessionsENST00000261535.7
A0A8V8TL90
A0A2P9DU05
A0A8V8TL82
ENST00000697752.1
Q14DU5
ENST00000315872.11
C9JFJ0
E9PF63
D6REE7
ENST00000697790.1
ENST00000401753.5
ENST00000431087.2
O75116