CNOT7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0000290Biological processdeadenylation-dependent decapping of nuclear-transcribed mRNA
GO_0035279Biological processmiRNA-mediated gene silencing by mRNA destabilization
GO_0010629Biological processnegative regulation of gene expression
GO_0060213Biological processpositive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO_0051607Biological processdefense response to virus
GO_0033962Biological processP-body assembly
GO_0045070Biological processpositive regulation of viral genome replication
GO_0006417Biological processregulation of translation
GO_1900153Biological processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0031047Biological processregulatory ncRNA-mediated gene silencing
GO_0000289Biological processnuclear-transcribed mRNA poly(A) tail shortening
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0000288Biological processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0042509Biological processregulation of tyrosine phosphorylation of STAT protein
GO_0061014Biological processpositive regulation of mRNA catabolic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0030015Cellular componentCCR4-NOT core complex
GO_0016020Cellular componentmembrane
GO_0016607Cellular componentnuclear speck
GO_0000932Cellular componentP-body
GO_0030014Cellular componentCCR4-NOT complex
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0043232Cellular componentintracellular non-membrane-bounded organelle
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0004532Molecular functionRNA exonuclease activity
GO_0003714Molecular functiontranscription corepressor activity
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0000175Molecular function3'-5'-RNA exonuclease activity
GO_0004535Molecular functionpoly(A)-specific ribonuclease activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCNOT7
Protein nameCCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (CCR4-associated factor 1)
CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (BTG1-binding factor 1) (CCR4-associated factor 1) (CAF-1) (Caf1a)
CCR4-NOT transcription complex subunit 7
SynonymsCAF1
DescriptionFUNCTION: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate . Its function seems to be partially redundant with that of CNOT8 . Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation . During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation . Additional complex functions may be a consequence of its influence on mRNA expression . Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity . .

AccessionsE5RJE0
E5RHV9
ENST00000518021.5
E5RGH2
ENST00000519954.5
ENST00000520178.3
ENST00000628418.1
Q9UIV1
ENST00000361272.9 [Q9UIV1-1]
ENST00000519918.5
ENST00000523917.5 [Q9UIV1-2]
H0YAV9
E5RGA8
ENST00000518541.5
H0YBT3
ENST00000524358.5