POU4F1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of POU4F1 at tissue level.

III. Associated gene sets

GO_2000679Biological processpositive regulation of transcription regulatory region DNA binding
GO_0007498Biological processmesoderm development
GO_0010629Biological processnegative regulation of gene expression
GO_0007507Biological processheart development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0031175Biological processneuron projection development
GO_0010628Biological processpositive regulation of gene expression
GO_0071392Biological processcellular response to estradiol stimulus
GO_0021953Biological processcentral nervous system neuron differentiation
GO_0048665Biological processneuron fate specification
GO_0001764Biological processneuron migration
GO_0003223Biological processventricular compact myocardium morphogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043069Biological processnegative regulation of programmed cell death
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0007409Biological processaxonogenesis
GO_0021559Biological processtrigeminal nerve development
GO_0045672Biological processpositive regulation of osteoclast differentiation
GO_0051402Biological processneuron apoptotic process
GO_0071345Biological processcellular response to cytokine stimulus
GO_0043066Biological processnegative regulation of apoptotic process
GO_0048935Biological processperipheral nervous system neuron development
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_0021535Biological processcell migration in hindbrain
GO_0051355Biological processproprioception involved in equilibrioception
GO_0021986Biological processhabenula development
GO_0050767Biological processregulation of neurogenesis
GO_0007416Biological processsynapse assembly
GO_0051090Biological processregulation of DNA-binding transcription factor activity
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0048880Biological processsensory system development
GO_0060384Biological processinnervation
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0001967Biological processsuckling behavior
GO_0005654Cellular componentnucleoplasm
GO_0043005Cellular componentneuron projection
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0051020Molecular functionGTPase binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePOU4F1
Protein namePOU domain, class 4, transcription factor 1 (Brain-specific homeobox/POU domain protein 3A) (Brain-3A) (Brn-3A) (Homeobox/POU domain protein RDC-1) (Oct-T1)
SynonymsBRN3A
RDC1
DescriptionFUNCTION: Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site. .; FUNCTION: [Isoform 2]: Able to act as transcription factor, cannot regulate the expression of the same subset of genes than isoform 1. Does not have antiapoptotic effect on neuronal cells. .

AccessionsQ01851
ENST00000377208.7 [Q01851-1]