CDKN1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0006978Biological processDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO_0031100Biological processanimal organ regeneration
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045740Biological processpositive regulation of DNA replication
GO_2000379Biological processpositive regulation of reactive oxygen species metabolic process
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0032091Biological processnegative regulation of protein binding
GO_0043616Biological processkeratinocyte proliferation
GO_0051726Biological processregulation of cell cycle
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0001701Biological processin utero embryonic development
GO_0090402Biological processoncogene-induced cell senescence
GO_0010629Biological processnegative regulation of gene expression
GO_0010389Biological processregulation of G2/M transition of mitotic cell cycle
GO_0071480Biological processcellular response to gamma radiation
GO_0042060Biological processwound healing
GO_0097193Biological processintrinsic apoptotic signaling pathway
GO_0043068Biological processpositive regulation of programmed cell death
GO_0010243Biological processresponse to organonitrogen compound
GO_0048144Biological processfibroblast proliferation
GO_0006606Biological processprotein import into nucleus
GO_1904044Biological processresponse to aldosterone
GO_1904030Biological processnegative regulation of cyclin-dependent protein kinase activity
GO_0006977Biological processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO_0060574Biological processintestinal epithelial cell maturation
GO_0045736Biological processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0071479Biological processcellular response to ionizing radiation
GO_0051412Biological processresponse to corticosterone
GO_0030308Biological processnegative regulation of cell growth
GO_0030216Biological processkeratinocyte differentiation
GO_0007265Biological processRas protein signal transduction
GO_0000079Biological processregulation of cyclin-dependent protein serine/threonine kinase activity
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_1902806Biological processregulation of cell cycle G1/S phase transition
GO_0090399Biological processreplicative senescence
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0046685Biological processresponse to arsenic-containing substance
GO_0042246Biological processtissue regeneration
GO_0071493Biological processcellular response to UV-B
GO_1905179Biological processnegative regulation of cardiac muscle tissue regeneration
GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_0055093Biological processresponse to hyperoxia
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0009636Biological processresponse to toxic substance
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0010165Biological processresponse to X-ray
GO_0034605Biological processcellular response to heat
GO_1904706Biological processnegative regulation of vascular associated smooth muscle cell proliferation
GO_0007507Biological processheart development
GO_0006974Biological processDNA damage response
GO_0071460Biological processcellular response to cell-matrix adhesion
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0090400Biological processstress-induced premature senescence
GO_0042326Biological processnegative regulation of phosphorylation
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0034198Biological processcellular response to amino acid starvation
GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0090398Biological processcellular senescence
GO_2000279Biological processnegative regulation of DNA biosynthetic process
GO_0005634Cellular componentnucleus
GO_0005730Cellular componentnucleolus
GO_0070557Cellular componentPCNA-p21 complex
GO_0005654Cellular componentnucleoplasm
GO_0000307Cellular componentcyclin-dependent protein kinase holoenzyme complex
GO_0016604Cellular componentnuclear body
GO_0032991Cellular componentprotein-containing complex
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005829Cellular componentcytosol
GO_0004860Molecular functionprotein kinase inhibitor activity
GO_0140677Molecular functionmolecular function activator activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0140311Molecular functionprotein sequestering activity
GO_0140678Molecular functionmolecular function inhibitor activity
GO_0019912Molecular functioncyclin-dependent protein kinase activating kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0030332Molecular functioncyclin binding
GO_0005515Molecular functionprotein binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0019901Molecular functionprotein kinase binding
GO_0004861Molecular functioncyclin-dependent protein serine/threonine kinase inhibitor activity

IV. Literature review

[source]
Gene nameCDKN1A
Protein nameCyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
SynonymsCIP1
MDA6
SDI1
CDKN1
CAP20
PIC1
WAF1
DescriptionFUNCTION: Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest . Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding . .

AccessionsENST00000244741.10
ENST00000615513.4
ENST00000448526.6
ENST00000373711.3
P38936
ENST00000405375.5