CELF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0006376Biological processmRNA splice site recognition
GO_0006397Biological processmRNA processing
GO_0010629Biological processnegative regulation of gene expression
GO_0010628Biological processpositive regulation of gene expression
GO_0016441Biological processpost-transcriptional gene silencing
GO_0061157Biological processmRNA destabilization
GO_0009792Biological processembryo development ending in birth or egg hatching
GO_0050727Biological processregulation of inflammatory response
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0035194Biological processregulatory ncRNA-mediated post-transcriptional gene silencing
GO_0007281Biological processgerm cell development
GO_0043484Biological processregulation of RNA splicing
GO_0017148Biological processnegative regulation of translation
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0010494Cellular componentcytoplasmic stress granule
GO_0097356Cellular componentperinucleolar compartment
GO_0005634Cellular componentnucleus
GO_0000900Molecular functionmRNA regulatory element binding translation repressor activity
GO_0003729Molecular functionmRNA binding
GO_0042835Molecular functionBRE binding
GO_0003723Molecular functionRNA binding
GO_0036002Molecular functionpre-mRNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCELF1
Protein nameCUGBP Elav-like family member 1
CUG triplet repeat, RNA binding protein 1, isoform CRA_c (CUGBP Elav-like family member 1)
CUGBP Elav-like family member 1 (CELF-1) (50 kDa nuclear polyadenylated RNA-binding protein) (Bruno-like protein 2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (CUG-BP- and ETR-3-like factor 1) (Deadenylation factor CUG-BP) (Embryo deadenylation element-binding protein homolog) (EDEN-BP homolog) (RNA-binding protein BRUNOL-2)
SynonymsBRUNOL2
hCG_25183
CUGBP
NAB50
CUGBP1
DescriptionFUNCTION: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA . .

AccessionsE9PKA1
ENST00000526419.1
ENST00000395292.6 [Q92879-3]
ENST00000535982.1
ENST00000526277.1
ENST00000525841.5
E9PSH0
ENST00000528538.5
ENST00000530151.5
F5H3J7
ENST00000531165.5
F5H0D8
G5EA30
ENST00000528434.5
F5H4Y5
ENST00000395290.6 [Q92879-6]
E9PQK4
ENST00000358597.7 [Q92879-1]
ENST00000361904.7 [Q92879-3]
F5H7M7
E9PKU1
ENST00000532048.5 [Q92879-4]
ENST00000310513.10 [Q92879-2]
ENST00000687097.1
Q92879
ENST00000543178.5