Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| intestine | 11 studies | 32% ± 16% | |
| lung | 11 studies | 30% ± 17% | |
| eye | 7 studies | 31% ± 9% | |
| kidney | 5 studies | 31% ± 8% | |
| prostate | 5 studies | 23% ± 4% | |
| uterus | 4 studies | 32% ± 13% | |
| breast | 4 studies | 31% ± 15% | |
| pancreas | 3 studies | 24% ± 7% | |
| esophagus | 3 studies | 52% ± 16% | |
| skin | 3 studies | 36% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 99% | 6926.52 | 454 / 459 | 99% | 124.08 | 1102 / 1118 |
| prostate | 98% | 7515.09 | 240 / 245 | 99% | 184.63 | 497 / 502 |
| thymus | 100% | 7552.51 | 651 / 653 | 97% | 177.94 | 587 / 605 |
| lung | 94% | 3637.08 | 545 / 578 | 96% | 105.53 | 1108 / 1155 |
| intestine | 91% | 2411.26 | 878 / 966 | 99% | 140.15 | 523 / 527 |
| uterus | 91% | 1946.55 | 155 / 170 | 98% | 178.93 | 448 / 459 |
| kidney | 100% | 5635.15 | 89 / 89 | 85% | 84.62 | 770 / 901 |
| esophagus | 81% | 3873.55 | 1164 / 1445 | 99% | 159.68 | 182 / 183 |
| bladder | 81% | 4458.29 | 17 / 21 | 98% | 182.57 | 496 / 504 |
| stomach | 78% | 1519.80 | 281 / 359 | 99% | 133.76 | 284 / 286 |
| pancreas | 77% | 1292.34 | 254 / 328 | 97% | 121.55 | 172 / 178 |
| liver | 85% | 2519.12 | 193 / 226 | 84% | 57.54 | 341 / 406 |
| skin | 73% | 8947.59 | 1315 / 1809 | 90% | 74.29 | 424 / 472 |
| ovary | 67% | 1658.25 | 121 / 180 | 91% | 86.32 | 392 / 430 |
| adrenal gland | 86% | 2167.62 | 222 / 258 | 61% | 36.27 | 141 / 230 |
| brain | 45% | 703.95 | 1179 / 2642 | 73% | 40.84 | 514 / 705 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 121.41 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 268.05 | 1 / 1 |
| blood vessel | 97% | 4533.55 | 1294 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 97% | 4289.53 | 1167 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 90% | 1667.88 | 217 / 241 | 0% | 0 | 0 / 0 |
| muscle | 87% | 2636.24 | 700 / 803 | 0% | 0 | 0 / 0 |
| heart | 76% | 2395.61 | 655 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 26% | 9.22 | 21 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 4.18 | 4 / 29 |
| peripheral blood | 7% | 89.76 | 64 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_2000974 | Biological process | negative regulation of pro-B cell differentiation |
| GO_0021984 | Biological process | adenohypophysis development |
| GO_0030324 | Biological process | lung development |
| GO_0035910 | Biological process | ascending aorta morphogenesis |
| GO_1905934 | Biological process | negative regulation of cell fate determination |
| GO_0021575 | Biological process | hindbrain morphogenesis |
| GO_0042098 | Biological process | T cell proliferation |
| GO_0042491 | Biological process | inner ear auditory receptor cell differentiation |
| GO_0060122 | Biological process | inner ear receptor cell stereocilium organization |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_0090102 | Biological process | cochlea development |
| GO_0030513 | Biological process | positive regulation of BMP signaling pathway |
| GO_0045598 | Biological process | regulation of fat cell differentiation |
| GO_0050767 | Biological process | regulation of neurogenesis |
| GO_0035881 | Biological process | amacrine cell differentiation |
| GO_0003143 | Biological process | embryonic heart tube morphogenesis |
| GO_0042102 | Biological process | positive regulation of T cell proliferation |
| GO_0007224 | Biological process | smoothened signaling pathway |
| GO_0003151 | Biological process | outflow tract morphogenesis |
| GO_0097150 | Biological process | neuronal stem cell population maintenance |
| GO_0003266 | Biological process | regulation of secondary heart field cardioblast proliferation |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0001709 | Biological process | cell fate determination |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0048711 | Biological process | positive regulation of astrocyte differentiation |
| GO_0097084 | Biological process | vascular associated smooth muscle cell development |
| GO_0071347 | Biological process | cellular response to interleukin-1 |
| GO_0007155 | Biological process | cell adhesion |
| GO_0003281 | Biological process | ventricular septum development |
| GO_1902870 | Biological process | negative regulation of amacrine cell differentiation |
| GO_0021870 | Biological process | Cajal-Retzius cell differentiation |
| GO_0048667 | Biological process | cell morphogenesis involved in neuron differentiation |
| GO_0060716 | Biological process | labyrinthine layer blood vessel development |
| GO_0060412 | Biological process | ventricular septum morphogenesis |
| GO_0072012 | Biological process | glomerulus vasculature development |
| GO_0061106 | Biological process | negative regulation of stomach neuroendocrine cell differentiation |
| GO_0007399 | Biological process | nervous system development |
| GO_0042531 | Biological process | positive regulation of tyrosine phosphorylation of STAT protein |
| GO_0021555 | Biological process | midbrain-hindbrain boundary morphogenesis |
| GO_0060164 | Biological process | regulation of timing of neuron differentiation |
| GO_0048715 | Biological process | negative regulation of oligodendrocyte differentiation |
| GO_0090162 | Biological process | establishment of epithelial cell polarity |
| GO_0043279 | Biological process | response to alkaloid |
| GO_0060675 | Biological process | ureteric bud morphogenesis |
| GO_0001889 | Biological process | liver development |
| GO_0003310 | Biological process | pancreatic A cell differentiation |
| GO_0043433 | Biological process | negative regulation of DNA-binding transcription factor activity |
| GO_0021861 | Biological process | forebrain radial glial cell differentiation |
| GO_0010977 | Biological process | negative regulation of neuron projection development |
| GO_0060253 | Biological process | negative regulation of glial cell proliferation |
| GO_0050678 | Biological process | regulation of epithelial cell proliferation |
| GO_1990090 | Biological process | cellular response to nerve growth factor stimulus |
| GO_0048538 | Biological process | thymus development |
| GO_0045608 | Biological process | negative regulation of inner ear auditory receptor cell differentiation |
| GO_0009952 | Biological process | anterior/posterior pattern specification |
| GO_0043388 | Biological process | positive regulation of DNA binding |
| GO_0043254 | Biological process | regulation of protein-containing complex assembly |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0021557 | Biological process | oculomotor nerve development |
| GO_0046331 | Biological process | lateral inhibition |
| GO_0072141 | Biological process | renal interstitial fibroblast development |
| GO_2000227 | Biological process | negative regulation of pancreatic A cell differentiation |
| GO_0048469 | Biological process | cell maturation |
| GO_2000978 | Biological process | negative regulation of forebrain neuron differentiation |
| GO_0046427 | Biological process | positive regulation of receptor signaling pathway via JAK-STAT |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0030901 | Biological process | midbrain development |
| GO_0016477 | Biological process | cell migration |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0035019 | Biological process | somatic stem cell population maintenance |
| GO_0071398 | Biological process | cellular response to fatty acid |
| GO_0048844 | Biological process | artery morphogenesis |
| GO_0097066 | Biological process | response to thyroid hormone |
| GO_0061009 | Biological process | common bile duct development |
| GO_0014070 | Biological process | response to organic cyclic compound |
| GO_0061309 | Biological process | cardiac neural crest cell development involved in outflow tract morphogenesis |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0090281 | Biological process | negative regulation of calcium ion import |
| GO_0065003 | Biological process | protein-containing complex assembly |
| GO_0071356 | Biological process | cellular response to tumor necrosis factor |
| GO_0072050 | Biological process | S-shaped body morphogenesis |
| GO_0045665 | Biological process | negative regulation of neuron differentiation |
| GO_0061102 | Biological process | stomach neuroendocrine cell differentiation |
| GO_2000737 | Biological process | negative regulation of stem cell differentiation |
| GO_0072282 | Biological process | metanephric nephron tubule morphogenesis |
| GO_0045977 | Biological process | positive regulation of mitotic cell cycle, embryonic |
| GO_0045747 | Biological process | positive regulation of Notch signaling pathway |
| GO_0061626 | Biological process | pharyngeal arch artery morphogenesis |
| GO_0021558 | Biological process | trochlear nerve development |
| GO_0046425 | Biological process | regulation of receptor signaling pathway via JAK-STAT |
| GO_0021537 | Biological process | telencephalon development |
| GO_0072049 | Biological process | comma-shaped body morphogenesis |
| GO_0005634 | Cellular component | nucleus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0016363 | Cellular component | nuclear matrix |
| GO_0001222 | Molecular function | transcription corepressor binding |
| GO_0070888 | Molecular function | E-box binding |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0042826 | Molecular function | histone deacetylase binding |
| GO_0008432 | Molecular function | JUN kinase binding |
| GO_0051087 | Molecular function | protein-folding chaperone binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0071820 | Molecular function | N-box binding |
| GO_0003677 | Molecular function | DNA binding |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0043398 | Molecular function | HLH domain binding |
| Gene name | HES1 |
| Protein name | Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial (Keio novel protein-I) (KNP-I) (Protein GT335) (Protein HES1) HES1 protein Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL) |
| Synonyms | GATD3B BHLHB39 KNPI HL HRY |
| Description | FUNCTION: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. . |
| Accessions | Q14469 A0A0B4J2D5 Q8IXV0 ENST00000232424.4 |
