MBD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0032355Biological processresponse to estradiol
GO_0010629Biological processnegative regulation of gene expression
GO_0048712Biological processnegative regulation of astrocyte differentiation
GO_0031667Biological processresponse to nutrient levels
GO_0030182Biological processneuron differentiation
GO_0042220Biological processresponse to cocaine
GO_0003229Biological processventricular cardiac muscle tissue development
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0040029Biological processepigenetic regulation of gene expression
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0003682Molecular functionchromatin binding
GO_0010385Molecular functiondouble-stranded methylated DNA binding
GO_0008327Molecular functionmethyl-CpG binding
GO_0008270Molecular functionzinc ion binding
GO_0045322Molecular functionunmethylated CpG binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMBD1
Protein nameMethyl-CpG binding domain protein 1
Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1)
SynonymsCXXC3
PCM1
DescriptionFUNCTION: Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. .

AccessionsENST00000339998.10 [Q9UIS9-6]
ENST00000588937.5 [Q9UIS9-2]
ENST00000347968.7 [Q9UIS9-7]
ENST00000398493.5 [Q9UIS9-7]
ENST00000269468.10 [Q9UIS9-1]
A0A994J7H0
K7EN65
ENST00000457839.6 [Q9UIS9-9]
ENST00000353909.7 [Q9UIS9-5]
ENST00000590215.1
ENST00000705655.1
K7EMA9
Q9UIS9
ENST00000585595.5 [Q9UIS9-9]
ENST00000589733.1
ENST00000398488.5 [Q9UIS9-4]
ENST00000269471.9 [Q9UIS9-2]
ENST00000592060.5
ENST00000591416.5 [Q9UIS9-1]
A0A0A0MS90
ENST00000398495.6
K7EPZ6
ENST00000382948.9 [Q9UIS9-1]
ENST00000585672.5 [Q9UIS9-10]
ENST00000587605.5 [Q9UIS9-11]
ENST00000591535.5 [Q9UIS9-8]
ENST00000589541.5
ENST00000590208.5 [Q9UIS9-12]
K7EIN3