PARP9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0034356Biological processNAD biosynthesis via nicotinamide riboside salvage pathway
GO_0010629Biological processnegative regulation of gene expression
GO_0045087Biological processinnate immune response
GO_0006302Biological processdouble-strand break repair
GO_0060335Biological processpositive regulation of type II interferon-mediated signaling pathway
GO_0051607Biological processdefense response to virus
GO_0010608Biological processpost-transcriptional regulation of gene expression
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043086Biological processnegative regulation of catalytic activity
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0070212Biological processprotein poly-ADP-ribosylation
GO_0019082Biological processviral protein processing
GO_0035563Biological processpositive regulation of chromatin binding
GO_0060330Biological processregulation of response to type II interferon
GO_0002230Biological processpositive regulation of defense response to virus by host
GO_0016477Biological processcell migration
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0000077Biological processDNA damage checkpoint signaling
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0090734Cellular componentsite of DNA damage
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0016779Molecular functionnucleotidyltransferase activity
GO_0019899Molecular functionenzyme binding
GO_0004857Molecular functionenzyme inhibitor activity
GO_0003950Molecular functionNAD+ ADP-ribosyltransferase activity
GO_0042393Molecular functionhistone binding
GO_0097677Molecular functionSTAT family protein binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0070403Molecular functionNAD+ binding
GO_0072570Molecular functionADP-D-ribose binding
GO_0140802Molecular functionNAD+-protein-C-terminal glycine ADP-ribosyltransferase activity
GO_0044389Molecular functionubiquitin-like protein ligase binding
GO_1990404Molecular functionNAD+-protein ADP-ribosyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePARP9
Protein namePoly(ADP-ribose) polymerase family member 9
Protein mono-ADP-ribosyltransferase PARP9 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 9) (ARTD9) (B aggressive lymphoma protein) (Poly [ADP-ribose] polymerase 9) (PARP-9)
Poly (ADP-ribose) polymerase family, member 9, isoform CRA_b (Poly(ADP-ribose) polymerase family member 9)
SynonymsBAL1
hCG_17211
BAL
DescriptionFUNCTION: ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses . Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) . In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones . During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 . Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites . In response to DNA damage, PARP9-DTX3L complex is required for efficient non-homologous end joining (NHEJ); the complex function is negatively modulated by PARP9 activity . Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR) (By similarity). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation . Also suppresses PARP14-mediated STAT6 ADP-ribosylation . .

AccessionsENST00000466126.1
G5E9U8
Q8IXQ6
ENST00000360356.6 [Q8IXQ6-1]
C9K0E5
ENST00000492382.5
ENST00000462315.5 [Q8IXQ6-3]
ENST00000471785.5 [Q8IXQ6-2]
ENST00000682323.1 [Q8IXQ6-2]
ENST00000477522.6 [Q8IXQ6-2]