MSR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010744Biological processpositive regulation of macrophage derived foam cell differentiation
GO_0010629Biological processnegative regulation of gene expression
GO_0006898Biological processreceptor-mediated endocytosis
GO_0034381Biological processplasma lipoprotein particle clearance
GO_0010886Biological processpositive regulation of cholesterol storage
GO_0051649Biological processestablishment of localization in cell
GO_0006911Biological processphagocytosis, engulfment
GO_0097242Biological processamyloid-beta clearance
GO_0042953Biological processlipoprotein transport
GO_0071407Biological processcellular response to organic cyclic compound
GO_0030301Biological processcholesterol transport
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0030666Cellular componentendocytic vesicle membrane
GO_0034362Cellular componentlow-density lipoprotein particle
GO_0005581Cellular componentcollagen trimer
GO_0038024Molecular functioncargo receptor activity
GO_0001540Molecular functionamyloid-beta binding
GO_0005044Molecular functionscavenger receptor activity
GO_0030169Molecular functionlow-density lipoprotein particle binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMSR1
Protein nameMacrophage scavenger receptor 1
Macrophage scavenger receptor 1 (cDNA FLJ55770, highly similar to Macrophage scavenger receptor types I and II)
Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD antigen CD204)
SynonymsSCARA1
DescriptionFUNCTION: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) . Isoform III does not internalize acetylated LDL . .

AccessionsENST00000445506.6
ENST00000350896.3 [P21757-3]
E5RFW8
ENST00000381998.8 [P21757-2]
B4DDJ5
ENST00000518960.5
ENST00000519060.6
ENST00000522672.5
ENST00000262101.10 [P21757-1]
ENST00000518026.5
P21757
H0YBY2
E5RI91
E5RFI4
ENST00000355282.6 [P21757-3]