ABCC2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ABCC2 at tissue level.

III. Associated gene sets

GO_0006805Biological processxenobiotic metabolic process
GO_0006855Biological processxenobiotic transmembrane transport
GO_0098656Biological processmonoatomic anion transmembrane transport
GO_0010629Biological processnegative regulation of gene expression
GO_0055085Biological processtransmembrane transport
GO_0150104Biological processtransport across blood-brain barrier
GO_0070633Biological processtransepithelial transport
GO_1990962Biological processxenobiotic transport across blood-brain barrier
GO_0042167Biological processheme catabolic process
GO_0015721Biological processbile acid and bile salt transport
GO_0015723Biological processbilirubin transport
GO_0046618Biological processxenobiotic export from cell
GO_0071716Biological processleukotriene transport
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0009986Cellular componentcell surface
GO_0046581Cellular componentintercellular canaliculus
GO_0008514Molecular functionorganic anion transmembrane transporter activity
GO_0140359Molecular functionABC-type transporter activity
GO_0043225Molecular functionATPase-coupled inorganic anion transmembrane transporter activity
GO_0008559Molecular functionABC-type xenobiotic transporter activity
GO_0015431Molecular functionABC-type glutathione S-conjugate transporter activity
GO_0042910Molecular functionxenobiotic transmembrane transporter activity
GO_0005524Molecular functionATP binding
GO_0015127Molecular functionbilirubin transmembrane transporter activity
GO_0042626Molecular functionATPase-coupled transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameABCC2
Protein nameATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Multidrug resistance-associated protein 2)
ATP binding cassette subfamily C member 2
SynonymsMRP2
CMRP
CMOAT
CMOAT1
DescriptionFUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates . Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification . Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 . Transports sulfated bile salt such as taurolithocholate sulfate . Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors . Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine . .

AccessionsENST00000649493.1
A0A3B3IRZ2
ENST00000649932.1
A0A3B3IS94
Q92887
ENST00000648689.1
A0A3B3IRU4
A0A3B3ITG8
ENST00000648523.1
ENST00000647814.1
ENST00000648324.1