TFAP4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TFAP4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TFAP4 at tissue level.

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0010629Biological processnegative regulation of gene expression
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0043922Biological processnegative regulation by host of viral transcription
GO_0006978Biological processDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO_0065003Biological processprotein-containing complex assembly
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043923Biological processpositive regulation by host of viral transcription
GO_0043392Biological processnegative regulation of DNA binding
GO_1901990Biological processregulation of mitotic cell cycle phase transition
GO_0045736Biological processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0070888Molecular functionE-box binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameTFAP4
Protein nameTranscription factor AP-4
TFAP4 protein
Transcription factor AP-4 (Activating enhancer-binding protein 4) (Class C basic helix-loop-helix protein 41) (bHLHc41)
SynonymsBHLHC41
DescriptionFUNCTION: Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.

AccessionsQ6FHM5
I3L254
ENST00000572393.1
Q01664
I3L301
I3L4L6
ENST00000574639.1
ENST00000204517.11
ENST00000573476.1