TERF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031848Biological processprotection from non-homologous end joining at telomere
GO_0001701Biological processin utero embryonic development
GO_0032204Biological processregulation of telomere maintenance
GO_0010629Biological processnegative regulation of gene expression
GO_0031627Biological processtelomeric loop formation
GO_1905778Biological processnegative regulation of exonuclease activity
GO_0008089Biological processanterograde axonal transport
GO_0010628Biological processpositive regulation of gene expression
GO_0099088Biological processaxonal transport of messenger ribonucleoprotein complex
GO_1905839Biological processnegative regulation of telomeric D-loop disassembly
GO_1903770Biological processnegative regulation of beta-galactosidase activity
GO_1904357Biological processnegative regulation of telomere maintenance via telomere lengthening
GO_0032211Biological processnegative regulation of telomere maintenance via telomerase
GO_1904354Biological processnegative regulation of telomere capping
GO_0016233Biological processtelomere capping
GO_0032208Biological processnegative regulation of telomere maintenance via recombination
GO_0032210Biological processregulation of telomere maintenance via telomerase
GO_0070198Biological processprotein localization to chromosome, telomeric region
GO_0032206Biological processpositive regulation of telomere maintenance
GO_1904430Biological processnegative regulation of t-circle formation
GO_0006278Biological processRNA-templated DNA biosynthetic process
GO_1903824Biological processnegative regulation of telomere single strand break repair
GO_0000723Biological processtelomere maintenance
GO_0061820Biological processtelomeric D-loop disassembly
GO_0090398Biological processcellular senescence
GO_0051000Biological processpositive regulation of nitric-oxide synthase activity
GO_0032214Biological processnegative regulation of telomere maintenance via semi-conservative replication
GO_2000773Biological processnegative regulation of cellular senescence
GO_0000783Cellular componentnuclear telomere cap complex
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0000781Cellular componentchromosome, telomeric region
GO_0070187Cellular componentshelterin complex
GO_0001673Cellular componentmale germ cell nucleus
GO_1904115Cellular componentaxon cytoplasm
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0042162Molecular functiontelomeric DNA binding
GO_0003691Molecular functiondouble-stranded telomeric DNA binding
GO_0003720Molecular functiontelomerase activity
GO_0098505Molecular functionG-rich strand telomeric DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTERF2
Protein nameTelomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein)
Telomeric repeat binding factor 2
SynonymsTRF2
TRBF2
DescriptionFUNCTION: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length. .

AccessionsENST00000566750.5
H3BR06
V9GYM1
J3KSZ6
ENST00000569542.6
ENST00000569584.6
ENST00000566051.1
ENST00000254942.8 [Q15554-3]
J3KSJ9
ENST00000566257.5
J3KTN8
ENST00000569280.1
ENST00000567296.6 [Q15554-4]
ENST00000564982.6
H3BR37
U3KQ35
H3BTA7
ENST00000567841.1
Q15554