MYCN report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MYCN at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MYCN at tissue level.

III. Associated gene sets

GO_0010629Biological processnegative regulation of gene expression
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0019900Molecular functionkinase binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMYCN
Protein nameMYCN proto-oncogene, bHLH transcription factor
Alternative protein MYCN
N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37)
SynonymsNMYC
BHLHE37
DescriptionFUNCTION: Positively regulates the transcription of MYCNOS in neuroblastoma cells. .

AccessionsL8E744
ENST00000281043.4
P04198
ENST00000638417.1
A0A5P8TXN7
A0A1W2PPD9