KLF4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043154Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0071300Biological processcellular response to retinoic acid
GO_0090051Biological processnegative regulation of cell migration involved in sprouting angiogenesis
GO_1901653Biological processcellular response to peptide
GO_0006366Biological processtranscription by RNA polymerase II
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0048730Biological processepidermis morphogenesis
GO_0051247Biological processpositive regulation of protein metabolic process
GO_0120222Biological processregulation of blastocyst development
GO_0061436Biological processestablishment of skin barrier
GO_0010629Biological processnegative regulation of gene expression
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_1903672Biological processpositive regulation of sprouting angiogenesis
GO_0009913Biological processepidermal cell differentiation
GO_2000342Biological processnegative regulation of chemokine (C-X-C motif) ligand 2 production
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0071363Biological processcellular response to growth factor stimulus
GO_0071409Biological processcellular response to cycloheximide
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0048679Biological processregulation of axon regeneration
GO_0060761Biological processnegative regulation of response to cytokine stimulus
GO_0016525Biological processnegative regulation of angiogenesis
GO_0034115Biological processnegative regulation of heterotypic cell-cell adhesion
GO_1904998Biological processnegative regulation of leukocyte adhesion to arterial endothelial cell
GO_0035166Biological processpost-embryonic hemopoiesis
GO_0050728Biological processnegative regulation of inflammatory response
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045595Biological processregulation of cell differentiation
GO_0002067Biological processglandular epithelial cell differentiation
GO_0019827Biological processstem cell population maintenance
GO_0007500Biological processmesodermal cell fate determination
GO_0045429Biological processpositive regulation of nitric oxide biosynthetic process
GO_0048662Biological processnegative regulation of smooth muscle cell proliferation
GO_0032717Biological processnegative regulation of interleukin-8 production
GO_0051973Biological processpositive regulation of telomerase activity
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0002357Biological processdefense response to tumor cell
GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0071499Biological processcellular response to laminar fluid shear stress
GO_0046985Biological processpositive regulation of hemoglobin biosynthetic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0045444Biological processfat cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0035019Biological processsomatic stem cell population maintenance
GO_0031077Biological processpost-embryonic camera-type eye development
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0001221Molecular functiontranscription coregulator binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0008013Molecular functionbeta-catenin binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0042826Molecular functionhistone deacetylase binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0008270Molecular functionzinc ion binding
GO_0031490Molecular functionchromatin DNA binding
GO_0001010Molecular functionRNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKLF4
Protein nameKruppel-like factor 4 short isoform
Kruppel-like factor 4 (Gut)
KLF transcription factor 4
Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor)
SynonymsEZF
GKLF
DescriptionFUNCTION: Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. .

AccessionsB7ZBT2
ENST00000610832.1
ENST00000374672.5 [O43474-1]
L0R3V2
F2VTX5
ENST00000420475.1
O43474
A0A087X0S4