POU3F2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of POU3F2 at tissue level.

III. Associated gene sets

GO_0021869Biological processforebrain ventricular zone progenitor cell division
GO_0008544Biological processepidermis development
GO_0021897Biological processforebrain astrocyte development
GO_0010629Biological processnegative regulation of gene expression
GO_0048663Biological processneuron fate commitment
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0048665Biological processneuron fate specification
GO_0021979Biological processhypothalamus cell differentiation
GO_0022011Biological processmyelination in peripheral nervous system
GO_0030182Biological processneuron differentiation
GO_0061101Biological processneuroendocrine cell differentiation
GO_0045595Biological processregulation of cell differentiation
GO_0048666Biological processneuron development
GO_0050770Biological processregulation of axonogenesis
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0007399Biological processnervous system development
GO_0040018Biological processpositive regulation of multicellular organism growth
GO_0021799Biological processcerebral cortex radially oriented cell migration
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0021985Biological processneurohypophysis development
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePOU3F2
Protein namePOU domain, class 3, transcription factor 2 (Brain-specific homeobox/POU domain protein 2) (Brain-2) (Brn-2) (Nervous system-specific octamer-binding transcription factor N-Oct-3) (Octamer-binding protein 7) (Oct-7) (Octamer-binding transcription factor 7) (OTF-7)
SynonymsOTF7
BRN2
OCT7
DescriptionFUNCTION: Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity). .

AccessionsP20265
ENST00000328345.8 [P20265-1]