ANAPC2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ANAPC2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ANAPC2 at tissue level.

III. Associated gene sets

GO_0070979Biological processprotein K11-linked ubiquitination
GO_0051445Biological processregulation of meiotic cell cycle
GO_0031915Biological processpositive regulation of synaptic plasticity
GO_0045773Biological processpositive regulation of axon extension
GO_0010629Biological processnegative regulation of gene expression
GO_0007091Biological processmetaphase/anaphase transition of mitotic cell cycle
GO_0051301Biological processcell division
GO_0031145Biological processanaphase-promoting complex-dependent catabolic process
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0050775Biological processpositive regulation of dendrite morphogenesis
GO_0030154Biological processcell differentiation
GO_0007346Biological processregulation of mitotic cell cycle
GO_0090129Biological processpositive regulation of synapse maturation
GO_0007399Biological processnervous system development
GO_0005680Cellular componentanaphase-promoting complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameANAPC2
Protein nameAnaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2)
SynonymsAPC2
KIAA1406
DescriptionFUNCTION: Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. .

AccessionsENST00000323927.3 [Q9UJX6-1]
Q9UJX6