APLN report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of APLN at tissue level.

III. Associated gene sets

GO_0042756Biological processdrinking behavior
GO_0001525Biological processangiogenesis
GO_0010629Biological processnegative regulation of gene expression
GO_1904706Biological processnegative regulation of vascular associated smooth muscle cell proliferation
GO_0007165Biological processsignal transduction
GO_1905564Biological processpositive regulation of vascular endothelial cell proliferation
GO_0060976Biological processcoronary vasculature development
GO_0007369Biological processgastrulation
GO_1904022Biological processpositive regulation of G protein-coupled receptor internalization
GO_0006955Biological processimmune response
GO_0045776Biological processnegative regulation of blood pressure
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0045823Biological processpositive regulation of heart contraction
GO_0007595Biological processlactation
GO_0040037Biological processnegative regulation of fibroblast growth factor receptor signaling pathway
GO_0060183Biological processapelin receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005179Molecular functionhormone activity
GO_0005102Molecular functionsignaling receptor binding
GO_0031704Molecular functionapelin receptor binding

IV. Literature review

[source]
Gene nameAPLN
Protein nameApelin (APJ endogenous ligand) [Cleaved into: Apelin-36; Apelin-31; Apelin-28; Apelin-13]
SynonymsAPEL
DescriptionFUNCTION: Endogenous ligand for the apelin receptor (APLNR) . Drives internalization of the apelin receptor (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity). Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (By similarity). .; FUNCTION: (Microbial infection) Endogenous ligand for the apelin receptor (APLNR), an alternative coreceptor with CD4 for HIV-1 infection . Inhibits HIV-1 entry in cells coexpressing CD4 and APLNR . Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives . .

AccessionsENST00000429967.3
Q9ULZ1