PIK3CA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0001525Biological processangiogenesis
GO_0071333Biological processcellular response to glucose stimulus
GO_0035994Biological processresponse to muscle stretch
GO_0016242Biological processnegative regulation of macroautophagy
GO_0110053Biological processregulation of actin filament organization
GO_0032869Biological processcellular response to insulin stimulus
GO_2000270Biological processnegative regulation of fibroblast apoptotic process
GO_0010629Biological processnegative regulation of gene expression
GO_0043457Biological processregulation of cellular respiration
GO_0141068Biological processautosome genomic imprinting
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0031295Biological processT cell costimulation
GO_0043276Biological processanoikis
GO_0010592Biological processpositive regulation of lamellipodium assembly
GO_0043201Biological processresponse to L-leucine
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0001889Biological processliver development
GO_2000811Biological processnegative regulation of anoikis
GO_0001932Biological processregulation of protein phosphorylation
GO_0040014Biological processregulation of multicellular organism growth
GO_0014823Biological processresponse to activity
GO_0050852Biological processT cell receptor signaling pathway
GO_0060048Biological processcardiac muscle contraction
GO_0038084Biological processvascular endothelial growth factor signaling pathway
GO_0048015Biological processphosphatidylinositol-mediated signaling
GO_0055119Biological processrelaxation of cardiac muscle
GO_0086003Biological processcardiac muscle cell contraction
GO_0014870Biological processresponse to muscle inactivity
GO_0030168Biological processplatelet activation
GO_0071548Biological processresponse to dexamethasone
GO_0030036Biological processactin cytoskeleton organization
GO_0001944Biological processvasculature development
GO_0036092Biological processphosphatidylinositol-3-phosphate biosynthetic process
GO_0008286Biological processinsulin receptor signaling pathway
GO_1903544Biological processresponse to butyrate
GO_1905477Biological processpositive regulation of protein localization to membrane
GO_0043542Biological processendothelial cell migration
GO_0071464Biological processcellular response to hydrostatic pressure
GO_0006909Biological processphagocytosis
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0060612Biological processadipose tissue development
GO_0016310Biological processphosphorylation
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0032008Biological processpositive regulation of TOR signaling
GO_0016477Biological processcell migration
GO_0006006Biological processglucose metabolic process
GO_0030835Biological processnegative regulation of actin filament depolymerization
GO_0005886Cellular componentplasma membrane
GO_0005942Cellular componentphosphatidylinositol 3-kinase complex
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005943Cellular componentphosphatidylinositol 3-kinase complex, class IA
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005944Cellular componentphosphatidylinositol 3-kinase complex, class IB
GO_0030027Cellular componentlamellipodium
GO_0014704Cellular componentintercalated disc
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0043560Molecular functioninsulin receptor substrate binding
GO_0030295Molecular functionprotein kinase activator activity
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0016303Molecular function1-phosphatidylinositol-3-kinase activity
GO_0035005Molecular function1-phosphatidylinositol-4-phosphate 3-kinase activity
GO_0005515Molecular functionprotein binding
GO_0046934Molecular function1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity

IV. Literature review

[source]
Gene namePIK3CA
Protein namePhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153)
p110 alpha (EC 2.7.1.153)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153)
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform variant (EC 2.7.1.153)
Mutant phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Synonymsprotein
variant
DescriptionFUNCTION: Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides . Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) . PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others . Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity). .

AccessionsC9J951
Q4LE51
C9JAM9
ENST00000643187.1
A0A8A2FPJ2
A0A2R8Y2F6
A0A3G2C3N5
A0A2P0XI22
P42336
ENST00000675786.1
ENST00000468036.1
ENST00000477735.1
A0A6Q8PGV1
A0A6B9QKK2
ENST00000263967.4
A0A6Q8PGN9
E2I6G1
ENST00000674622.1
A0A6B9QIS5