HAND2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HAND2 at tissue level.

III. Associated gene sets

GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0071300Biological processcellular response to retinoic acid
GO_2000679Biological processpositive regulation of transcription regulatory region DNA binding
GO_0001525Biological processangiogenesis
GO_0003151Biological processoutflow tract morphogenesis
GO_0061325Biological processcell proliferation involved in outflow tract morphogenesis
GO_0003266Biological processregulation of secondary heart field cardioblast proliferation
GO_0061032Biological processvisceral serous pericardium development
GO_0001701Biological processin utero embryonic development
GO_0048485Biological processsympathetic nervous system development
GO_0010629Biological processnegative regulation of gene expression
GO_0007507Biological processheart development
GO_0001947Biological processheart looping
GO_0001649Biological processosteoblast differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010613Biological processpositive regulation of cardiac muscle hypertrophy
GO_0042421Biological processnorepinephrine biosynthetic process
GO_0010628Biological processpositive regulation of gene expression
GO_0042733Biological processembryonic digit morphogenesis
GO_0003357Biological processnoradrenergic neuron differentiation
GO_0061309Biological processcardiac neural crest cell development involved in outflow tract morphogenesis
GO_0043586Biological processtongue development
GO_1900745Biological processpositive regulation of p38MAPK cascade
GO_0060536Biological processcartilage morphogenesis
GO_0048706Biological processembryonic skeletal system development
GO_0048935Biological processperipheral nervous system neuron development
GO_0007512Biological processadult heart development
GO_0048538Biological processthymus development
GO_0010463Biological processmesenchymal cell proliferation
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0034103Biological processregulation of tissue remodeling
GO_1904036Biological processnegative regulation of epithelial cell apoptotic process
GO_0003219Biological processcardiac right ventricle formation
GO_1904019Biological processepithelial cell apoptotic process
GO_0060982Biological processcoronary artery morphogenesis
GO_2001262Biological processpositive regulation of semaphorin-plexin signaling pathway
GO_0010667Biological processnegative regulation of cardiac muscle cell apoptotic process
GO_0003278Biological processapoptotic process involved in heart morphogenesis
GO_0003253Biological processcardiac neural crest cell migration involved in outflow tract morphogenesis
GO_1903929Biological processprimary palate development
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0071407Biological processcellular response to organic cyclic compound
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0001967Biological processsuckling behavior
GO_0032991Cellular componentprotein-containing complex
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0001223Molecular functiontranscription coactivator binding
GO_0003680Molecular functionminor groove of adenine-thymine-rich DNA binding
GO_0070888Molecular functionE-box binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHAND2
Protein nameHeart- and neural crest derivatives-expressed protein 2 (Class A basic helix-loop-helix protein 26) (bHLHa26) (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND)
HAND2 protein
Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2)
SynonymsBHLHA26
DHAND
hCG_1743431
DescriptionFUNCTION: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). .

AccessionsH0YAH1
ENST00000359562.4 [P61296-1]
Q32LY2
P61296
Q3T1D5
B3KV85
ENST00000503024.1