ACACB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0007584Biological processresponse to nutrient
GO_0031999Biological processnegative regulation of fatty acid beta-oxidation
GO_0006098Biological processpentose-phosphate shunt
GO_0046722Biological processlactic acid secretion
GO_0010629Biological processnegative regulation of gene expression
GO_0019395Biological processfatty acid oxidation
GO_0090461Biological processintracellular glutamate homeostasis
GO_1903242Biological processregulation of cardiac muscle hypertrophy in response to stress
GO_0090459Biological processintracellular aspartate homeostasis
GO_0014070Biological processresponse to organic cyclic compound
GO_0010906Biological processregulation of glucose metabolic process
GO_0051289Biological processprotein homotetramerization
GO_0006084Biological processacetyl-CoA metabolic process
GO_0006633Biological processfatty acid biosynthetic process
GO_0060421Biological processpositive regulation of heart growth
GO_0072350Biological processtricarboxylic acid metabolic process
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0046323Biological processglucose import
GO_2001295Biological processmalonyl-CoA biosynthetic process
GO_0010884Biological processpositive regulation of lipid storage
GO_0005739Cellular componentmitochondrion
GO_0016507Cellular componentmitochondrial fatty acid beta-oxidation multienzyme complex
GO_0005829Cellular componentcytosol
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0003989Molecular functionacetyl-CoA carboxylase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0009374Molecular functionbiotin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameACACB
Protein nameACACB protein
Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta)
Acetyl-CoA carboxylase beta
SynonymsACCB
ACC2
DescriptionFUNCTION: Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism . Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA . Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity). .

AccessionsENST00000338432.12 [O00763-1]
ENST00000536440.2
H0YGH5
ENST00000538526.5
F8W8T8
S4R3S7
ENST00000544726.2
ENST00000377848.7 [O00763-1]
F5H5C3
Q4G170
O00763
A0A087WUA1
ENST00000539864.1
ENST00000377854.9