BAK1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BAK1 at tissue level.

III. Associated gene sets

GO_0090200Biological processpositive regulation of release of cytochrome c from mitochondria
GO_0050673Biological processepithelial cell proliferation
GO_0042542Biological processresponse to hydrogen peroxide
GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0097190Biological processapoptotic signaling pathway
GO_0002262Biological processmyeloid cell homeostasis
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0034620Biological processcellular response to unfolded protein
GO_0001974Biological processblood vessel remodeling
GO_1901030Biological processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO_0071260Biological processcellular response to mechanical stimulus
GO_0010524Biological processpositive regulation of calcium ion transport into cytosol
GO_0010629Biological processnegative regulation of gene expression
GO_0001783Biological processB cell apoptotic process
GO_0034644Biological processcellular response to UV
GO_0045862Biological processpositive regulation of proteolysis
GO_0032471Biological processnegative regulation of endoplasmic reticulum calcium ion concentration
GO_0010332Biological processresponse to gamma radiation
GO_0010225Biological processresponse to UV-C
GO_0048597Biological processpost-embryonic camera-type eye morphogenesis
GO_0090201Biological processnegative regulation of release of cytochrome c from mitochondria
GO_1903896Biological processpositive regulation of IRE1-mediated unfolded protein response
GO_0009620Biological processresponse to fungus
GO_0014070Biological processresponse to organic cyclic compound
GO_0008053Biological processmitochondrial fusion
GO_0001782Biological processB cell homeostasis
GO_0031100Biological processanimal organ regeneration
GO_0045471Biological processresponse to ethanol
GO_1901029Biological processnegative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO_0070242Biological processthymocyte apoptotic process
GO_0051649Biological processestablishment of localization in cell
GO_0097202Biological processactivation of cysteine-type endopeptidase activity
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_0051881Biological processregulation of mitochondrial membrane potential
GO_0097193Biological processintrinsic apoptotic signaling pathway
GO_0060068Biological processvagina development
GO_1900103Biological processpositive regulation of endoplasmic reticulum unfolded protein response
GO_1902262Biological processapoptotic process involved in blood vessel morphogenesis
GO_0097192Biological processextrinsic apoptotic signaling pathway in absence of ligand
GO_0010248Biological processestablishment or maintenance of transmembrane electrochemical gradient
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0001836Biological processrelease of cytochrome c from mitochondria
GO_0035108Biological processlimb morphogenesis
GO_0006915Biological processapoptotic process
GO_0046902Biological processregulation of mitochondrial membrane permeability
GO_0031018Biological processendocrine pancreas development
GO_0060402Biological processcalcium ion transport into cytosol
GO_0033137Biological processnegative regulation of peptidyl-serine phosphorylation
GO_0002352Biological processB cell negative selection
GO_0010046Biological processresponse to mycotoxin
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0044346Biological processfibroblast apoptotic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_0032469Biological processendoplasmic reticulum calcium ion homeostasis
GO_0051726Biological processregulation of cell cycle
GO_0005739Cellular componentmitochondrion
GO_0097145Cellular componentBAK complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0046930Cellular componentpore complex
GO_0005741Cellular componentmitochondrial outer membrane
GO_0097136Cellular componentBcl-2 family protein complex
GO_0015288Molecular functionporin activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0031072Molecular functionheat shock protein binding
GO_0042802Molecular functionidentical protein binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0046872Molecular functionmetal ion binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0051400Molecular functionBH domain binding
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameBAK1
Protein nameBCL2-antagonist/killer 1 isoform 2
Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7)
BCL2-antagonist/killer 1 isoform 1
SynonymsBAK
CDN1
BCL2L7
DescriptionFUNCTION: Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. .

AccessionsENST00000374467.4 [Q16611-1]
Q16611
A0A0S2Z319
A0A0S2Z391
ENST00000442998.6 [Q16611-2]