PIAS3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PIAS3 at tissue level.

III. Associated gene sets

GO_0045671Biological processnegative regulation of osteoclast differentiation
GO_0016925Biological processprotein sumoylation
GO_0033235Biological processpositive regulation of protein sumoylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_0010629Biological processnegative regulation of gene expression
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0033234Biological processnegative regulation of protein sumoylation
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005737Cellular componentcytoplasm
GO_0019789Molecular functionSUMO transferase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0061665Molecular functionSUMO ligase activity

IV. Literature review

[source]
Gene namePIAS3
Protein namePIAS3 protein (Protein inhibitor of activated STAT3)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Protein inhibitor of activated STAT, 3, isoform CRA_b
Protein inhibitor of activated STAT 3
SynonymshCG_37029
DKFZp434O0617
DescriptionFUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation . Sumoylates CCAR2 which promotes its interaction with SIRT1 . Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus . .

AccessionsE9PHH8
U3KQV1
ENST00000393045.7
Q6IAR4
ENST00000393046.3
E7ESB4
ENST00000463514.2
ENST00000369298.5
Q9UFA8
Q9Y6X2