DNMT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032259Biological processmethylation
GO_0010629Biological processnegative regulation of gene expression
GO_0010628Biological processpositive regulation of gene expression
GO_0006346Biological processDNA methylation-dependent heterochromatin formation
GO_1903926Biological processcellular response to bisphenol A
GO_0044027Biological processnegative regulation of gene expression via chromosomal CpG island methylation
GO_0043045Biological processepigenetic programming of gene expression
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006351Biological processDNA-templated transcription
GO_0141119Biological processchromosomal DNA methylation maintenance following DNA replication
GO_0071230Biological processcellular response to amino acid stimulus
GO_1905931Biological processnegative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
GO_1905460Biological processnegative regulation of vascular associated smooth muscle cell apoptotic process
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_0005657Cellular componentreplication fork
GO_0005654Cellular componentnucleoplasm
GO_0001674Cellular componentfemale germ cell nucleus
GO_0005721Cellular componentpericentric heterochromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0003886Molecular functionDNA (cytosine-5-)-methyltransferase activity
GO_0008327Molecular functionmethyl-CpG binding
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding
GO_0009008Molecular functionDNA-methyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDNMT1
Protein nameDNA (cytosine-5)-methyltransferase (EC 2.1.1.37)
DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37)
DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
DNA methyltransferase 1
SynonymsDNMT
AIM
CXXC9
DescriptionFUNCTION: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells . Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) . Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing . Promotes tumor growth . .

AccessionsENST00000588118.5
K7EJL0
ENST00000677013.1
A0A7I2V490
A0A7I2V5F1
ENST00000592342.5
ENST00000586799.1
ENST00000590619.1
K7EMU8
ENST00000588913.5
ENST00000592054.5
ENST00000677946.1
ENST00000677634.1
ENST00000588952.5
ENST00000678804.1
K7ER10
A0A7I2V3F8
P26358
ENST00000676610.1
ENST00000677250.1
ENST00000340748.8 [P26358-1]
ENST00000359526.9 [P26358-2]
ENST00000586988.5
K7ELB1
ENST00000679103.1
A0A7I2V5F6
ENST00000592705.5
A0A7I2V5D0
I6L9H2
K7ENQ6
ENST00000586800.5
A0A7I2YQA8
A0A7I2YQQ0
K7ENW7
ENST00000677685.1
K7EKC3
K7EIZ6
ENST00000677616.1
A0A7I2V311
ENST00000679313.1
K7EP77
A0A7I2V2G5
K7ERQ1