TERT report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TERT at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TERT at tissue level.

III. Associated gene sets

GO_2000352Biological processnegative regulation of endothelial cell apoptotic process
GO_0022616Biological processDNA strand elongation
GO_0046326Biological processpositive regulation of glucose import
GO_0010629Biological processnegative regulation of gene expression
GO_0045766Biological processpositive regulation of angiogenesis
GO_1904751Biological processpositive regulation of protein localization to nucleolus
GO_1904754Biological processpositive regulation of vascular associated smooth muscle cell migration
GO_0032092Biological processpositive regulation of protein binding
GO_2000773Biological processnegative regulation of cellular senescence
GO_0001172Biological processRNA-templated transcription
GO_2000648Biological processpositive regulation of stem cell proliferation
GO_0090399Biological processreplicative senescence
GO_0140745Biological processsiRNA transcription
GO_1903620Biological processpositive regulation of transdifferentiation
GO_1900087Biological processpositive regulation of G1/S transition of mitotic cell cycle
GO_0046686Biological processresponse to cadmium ion
GO_0042635Biological processpositive regulation of hair cycle
GO_0071897Biological processDNA biosynthetic process
GO_0007005Biological processmitochondrion organization
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0006278Biological processRNA-templated DNA biosynthetic process
GO_0000723Biological processtelomere maintenance
GO_0030422Biological processsiRNA processing
GO_2001240Biological processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0051000Biological processpositive regulation of nitric-oxide synthase activity
GO_0070200Biological processestablishment of protein localization to telomere
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_0030177Biological processpositive regulation of Wnt signaling pathway
GO_0031647Biological processregulation of protein stability
GO_0071456Biological processcellular response to hypoxia
GO_0007004Biological processtelomere maintenance via telomerase
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0042645Cellular componentmitochondrial nucleoid
GO_0016607Cellular componentnuclear speck
GO_0000783Cellular componentnuclear telomere cap complex
GO_0005654Cellular componentnucleoplasm
GO_0005697Cellular componenttelomerase holoenzyme complex
GO_1990572Cellular componentTERT-RMRP complex
GO_0005829Cellular componentcytosol
GO_0000333Cellular componenttelomerase catalytic core complex
GO_0031379Cellular componentRNA-directed RNA polymerase complex
GO_0016605Cellular componentPML body
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0098680Molecular functiontemplate-free RNA nucleotidyltransferase
GO_0042162Molecular functiontelomeric DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0003964Molecular functionRNA-directed DNA polymerase activity
GO_0001223Molecular functiontranscription coactivator binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0003720Molecular functiontelomerase activity
GO_0046872Molecular functionmetal ion binding
GO_0070034Molecular functiontelomerase RNA binding
GO_0003723Molecular functionRNA binding
GO_0003721Molecular functiontelomerase RNA reverse transcriptase activity
GO_0003968Molecular functionRNA-dependent RNA polymerase activity
GO_0000049Molecular functiontRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTERT
Protein nameTelomerase reverse transcriptase (EC 2.7.7.49) (Telomerase catalytic subunit)
Telomerase reverse transcriptase
Telomerase catalytic subunit
Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2)
SynonymshCG_1990943
EST2
TCS1
TRT
DescriptionFUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. .

FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. .

FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. .

FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. .

FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. .

FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. .

AccessionsA0A590UK92
Q9UQ24
F6MZ68
ENST00000334602.10 [O14746-3]
Q9UNR4
ENST00000310581.10 [O14746-1]
O14746
ENST00000656021.1
F6MZ67
Q9UNS6
Q9UBR6
ENST00000460137.6 [O14746-4]