Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 13 studies | 35% ± 14% | |
glutamatergic neuron | 12 studies | 52% ± 25% | |
oligodendrocyte precursor cell | 12 studies | 43% ± 19% | |
GABAergic neuron | 11 studies | 48% ± 24% | |
pericyte | 8 studies | 34% ± 13% | |
adipocyte | 8 studies | 36% ± 9% | |
retinal ganglion cell | 7 studies | 49% ± 19% | |
endothelial cell | 6 studies | 35% ± 17% | |
interneuron | 6 studies | 58% ± 21% | |
epithelial cell | 5 studies | 33% ± 9% | |
smooth muscle cell | 5 studies | 33% ± 9% | |
neuron | 4 studies | 40% ± 11% | |
cardiac muscle cell | 4 studies | 24% ± 2% | |
Mueller cell | 4 studies | 36% ± 11% | |
ON-bipolar cell | 4 studies | 43% ± 19% | |
retinal cone cell | 4 studies | 27% ± 8% | |
endothelial cell of lymphatic vessel | 4 studies | 27% ± 5% | |
oligodendrocyte | 4 studies | 29% ± 10% | |
GABAergic interneuron | 3 studies | 51% ± 7% | |
progenitor cell | 3 studies | 30% ± 18% | |
ciliated cell | 3 studies | 22% ± 5% | |
GABAergic amacrine cell | 3 studies | 33% ± 10% | |
OFF-bipolar cell | 3 studies | 42% ± 5% | |
glycinergic amacrine cell | 3 studies | 21% ± 7% | |
retinal rod cell | 3 studies | 20% ± 4% | |
rod bipolar cell | 3 studies | 35% ± 17% | |
ependymal cell | 3 studies | 36% ± 14% | |
fibroblast | 3 studies | 18% ± 3% | |
granule cell | 3 studies | 26% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 1678.53 | 2639 / 2642 | 100% | 6.62 | 702 / 705 |
prostate | 100% | 750.45 | 244 / 245 | 97% | 2.60 | 485 / 502 |
uterus | 100% | 946.34 | 170 / 170 | 88% | 5.29 | 406 / 459 |
thymus | 100% | 1046.92 | 653 / 653 | 84% | 2.15 | 509 / 605 |
esophagus | 100% | 1180.43 | 1445 / 1445 | 80% | 5.95 | 147 / 183 |
bladder | 100% | 1172.90 | 21 / 21 | 76% | 3.36 | 384 / 504 |
lung | 98% | 656.44 | 565 / 578 | 72% | 4.84 | 832 / 1155 |
adrenal gland | 86% | 368.33 | 223 / 258 | 74% | 3.21 | 170 / 230 |
breast | 100% | 1082.87 | 458 / 459 | 60% | 1.90 | 671 / 1118 |
kidney | 91% | 366.34 | 81 / 89 | 57% | 1.15 | 514 / 901 |
intestine | 98% | 906.45 | 948 / 966 | 39% | 0.89 | 204 / 527 |
skin | 72% | 356.58 | 1302 / 1809 | 58% | 1.70 | 272 / 472 |
stomach | 88% | 514.65 | 316 / 359 | 37% | 1.05 | 106 / 286 |
ovary | 78% | 365.47 | 141 / 180 | 34% | 0.69 | 147 / 430 |
adipose | 100% | 1212.21 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1665.41 | 1335 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 6.51 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 2.96 | 1 / 1 |
heart | 96% | 983.46 | 830 / 861 | 0% | 0 | 0 / 0 |
spleen | 87% | 310.00 | 209 / 241 | 0% | 0 | 0 / 0 |
pancreas | 17% | 48.07 | 56 / 328 | 62% | 1.47 | 110 / 178 |
muscle | 65% | 217.17 | 518 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 61% | 1.57 | 49 / 80 |
lymph node | 0% | 0 | 0 / 0 | 59% | 1.28 | 17 / 29 |
liver | 1% | 2.11 | 2 / 226 | 7% | 0.20 | 30 / 406 |
peripheral blood | 3% | 14.32 | 31 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_0010629 | Biological process | negative regulation of gene expression |
GO_0010628 | Biological process | positive regulation of gene expression |
GO_0001764 | Biological process | neuron migration |
GO_0007010 | Biological process | cytoskeleton organization |
GO_0050773 | Biological process | regulation of dendrite development |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0010719 | Biological process | negative regulation of epithelial to mesenchymal transition |
GO_0000226 | Biological process | microtubule cytoskeleton organization |
GO_0010975 | Biological process | regulation of neuron projection development |
GO_0016055 | Biological process | Wnt signaling pathway |
GO_0006468 | Biological process | protein phosphorylation |
GO_0051654 | Biological process | establishment of mitochondrion localization |
GO_0005856 | Cellular component | cytoskeleton |
GO_0005886 | Cellular component | plasma membrane |
GO_0030425 | Cellular component | dendrite |
GO_0015630 | Cellular component | microtubule cytoskeleton |
GO_0005737 | Cellular component | cytoplasm |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0005546 | Molecular function | phosphatidylinositol-4,5-bisphosphate binding |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0001786 | Molecular function | phosphatidylserine binding |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0050321 | Molecular function | tau-protein kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0048156 | Molecular function | tau protein binding |
GO_0070300 | Molecular function | phosphatidic acid binding |
GO_0005515 | Molecular function | protein binding |
Gene name | MARK1 |
Protein name | non-specific serine/threonine protein kinase (EC 2.7.11.1) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) MAP/microtubule affinity-regulating kinase 1 isoform A Microtubule affinity regulating kinase 1 |
Synonyms | MARK KIAA1477 hCG_25120 |
Description | FUNCTION: Serine/threonine-protein kinase . Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU . Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). . |
Accessions | A0A7I2V624 X5D2M4 X5DNR8 ENST00000678435.1 ENST00000677041.1 A0A7I2V4P8 A0A087X0I6 ENST00000366918.8 [Q9P0L2-3] B4DIB3 X5D9P2 ENST00000611084.4 ENST00000402574.5 A0A7I2V550 ENST00000677505.1 A0A7I2YQC1 X5D7J4 ENST00000366917.6 [Q9P0L2-1] Q9P0L2 ENST00000679033.1 |