MARK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0010629Biological processnegative regulation of gene expression
GO_0010628Biological processpositive regulation of gene expression
GO_0001764Biological processneuron migration
GO_0007010Biological processcytoskeleton organization
GO_0050773Biological processregulation of dendrite development
GO_0035556Biological processintracellular signal transduction
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0010975Biological processregulation of neuron projection development
GO_0016055Biological processWnt signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0051654Biological processestablishment of mitochondrion localization
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0030425Cellular componentdendrite
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0106310Molecular functionprotein serine kinase activity
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0001786Molecular functionphosphatidylserine binding
GO_0000287Molecular functionmagnesium ion binding
GO_0050321Molecular functiontau-protein kinase activity
GO_0005524Molecular functionATP binding
GO_0048156Molecular functiontau protein binding
GO_0070300Molecular functionphosphatidic acid binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMARK1
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c)
MAP/microtubule affinity-regulating kinase 1 isoform A
Microtubule affinity regulating kinase 1
SynonymsMARK
KIAA1477
hCG_25120
DescriptionFUNCTION: Serine/threonine-protein kinase . Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU . Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). .

AccessionsA0A7I2V624
X5D2M4
X5DNR8
ENST00000678435.1
ENST00000677041.1
A0A7I2V4P8
A0A087X0I6
ENST00000366918.8 [Q9P0L2-3]
B4DIB3
X5D9P2
ENST00000611084.4
ENST00000402574.5
A0A7I2V550
ENST00000677505.1
A0A7I2YQC1
X5D7J4
ENST00000366917.6 [Q9P0L2-1]
Q9P0L2
ENST00000679033.1