HEYL report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HEYL at tissue level.

III. Associated gene sets

GO_0003151Biological processoutflow tract morphogenesis
GO_0003198Biological processepithelial to mesenchymal transition involved in endocardial cushion formation
GO_0007219Biological processNotch signaling pathway
GO_0071773Biological processcellular response to BMP stimulus
GO_0010629Biological processnegative regulation of gene expression
GO_0072014Biological processproximal tubule development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0003181Biological processatrioventricular valve morphogenesis
GO_0003180Biological processaortic valve morphogenesis
GO_0003203Biological processendocardial cushion morphogenesis
GO_0072359Biological processcirculatory system development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0060317Biological processcardiac epithelial to mesenchymal transition
GO_0003208Biological processcardiac ventricle morphogenesis
GO_0014031Biological processmesenchymal cell development
GO_0060412Biological processventricular septum morphogenesis
GO_0060766Biological processnegative regulation of androgen receptor signaling pathway
GO_0009952Biological processanterior/posterior pattern specification
GO_0032835Biological processglomerulus development
GO_0003184Biological processpulmonary valve morphogenesis
GO_0050767Biological processregulation of neurogenesis
GO_0035914Biological processskeletal muscle cell differentiation
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0050683Molecular functionAF-1 domain binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHEYL
Protein nameHairy/enhancer-of-split related with YRPW motif-like protein (hHeyL) (Class B basic helix-loop-helix protein 33) (bHLHb33) (Hairy-related transcription factor 3) (HRT-3) (hHRT3)
SynonymsBHLHB33
HRT3
DescriptionFUNCTION: Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. .

AccessionsQ9NQ87
ENST00000372852.4