IGF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000679Biological processpositive regulation of transcription regulatory region DNA binding
GO_0042104Biological processpositive regulation of activated T cell proliferation
GO_0010468Biological processregulation of gene expression
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0008283Biological processcell population proliferation
GO_0061051Biological processpositive regulation of cell growth involved in cardiac muscle cell development
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0150079Biological processnegative regulation of neuroinflammatory response
GO_0001775Biological processcell activation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0050821Biological processprotein stabilization
GO_0046579Biological processpositive regulation of Ras protein signal transduction
GO_0001501Biological processskeletal system development
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0010560Biological processpositive regulation of glycoprotein biosynthetic process
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_0009408Biological processresponse to heat
GO_0010629Biological processnegative regulation of gene expression
GO_0007165Biological processsignal transduction
GO_0010628Biological processpositive regulation of gene expression
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0014911Biological processpositive regulation of smooth muscle cell migration
GO_0032691Biological processnegative regulation of interleukin-1 beta production
GO_0042060Biological processwound healing
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0051450Biological processmyoblast proliferation
GO_0043568Biological processpositive regulation of insulin-like growth factor receptor signaling pathway
GO_0045821Biological processpositive regulation of glycolytic process
GO_0014834Biological processskeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0007265Biological processRas protein signal transduction
GO_0032148Biological processactivation of protein kinase B activity
GO_0009441Biological processglycolate metabolic process
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_1902430Biological processnegative regulation of amyloid-beta formation
GO_0070886Biological processpositive regulation of calcineurin-NFAT signaling cascade
GO_0090201Biological processnegative regulation of release of cytochrome c from mitochondria
GO_0034392Biological processnegative regulation of smooth muscle cell apoptotic process
GO_0050714Biological processpositive regulation of protein secretion
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045445Biological processmyoblast differentiation
GO_0007517Biological processmuscle organ development
GO_0043388Biological processpositive regulation of DNA binding
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0060283Biological processnegative regulation of oocyte development
GO_1905460Biological processnegative regulation of vascular associated smooth muscle cell apoptotic process
GO_1904646Biological processcellular response to amyloid-beta
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0001837Biological processepithelial to mesenchymal transition
GO_0030166Biological processproteoglycan biosynthetic process
GO_0014904Biological processmyotube cell development
GO_0046326Biological processpositive regulation of glucose import
GO_0010613Biological processpositive regulation of cardiac muscle hypertrophy
GO_0001932Biological processregulation of protein phosphorylation
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0045725Biological processpositive regulation of glycogen biosynthetic process
GO_1904075Biological processpositive regulation of trophectodermal cell proliferation
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0030335Biological processpositive regulation of cell migration
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0035630Biological processbone mineralization involved in bone maturation
GO_0014896Biological processmuscle hypertrophy
GO_0045840Biological processpositive regulation of mitotic nuclear division
GO_0070382Cellular componentexocytic vesicle
GO_0005576Cellular componentextracellular region
GO_0042567Cellular componentinsulin-like growth factor ternary complex
GO_0031093Cellular componentplatelet alpha granule lumen
GO_0016942Cellular componentinsulin-like growth factor binding protein complex
GO_0005615Cellular componentextracellular space
GO_0035867Cellular componentalphav-beta3 integrin-IGF-1-IGF1R complex
GO_0005179Molecular functionhormone activity
GO_0005515Molecular functionprotein binding
GO_0005158Molecular functioninsulin receptor binding
GO_0005159Molecular functioninsulin-like growth factor receptor binding
GO_0008083Molecular functiongrowth factor activity
GO_0005178Molecular functionintegrin binding

IV. Literature review

[source]
Gene nameIGF1
Protein nameAlternative protein IGF1
Insulin-like growth factor I (IGF-I) (Mechano growth factor) (MGF) (Somatomedin-C)
Insulin-like growth factor I
Insulin-like growth factor-I
SynonymshCG_21873
IBP1
DescriptionFUNCTION: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation . Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 . As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). .

AccessionsENST00000337514.11 [P05019-2]
ENST00000307046.8 [P05019-1]
L8E8N9
Q9NP10
Q6LD41
L8EC78
ENST00000392904.5 [P05019-4]
ENST00000424202.6 [P05019-3]
ENST00000644491.1 [P05019-2]
Q5U743
P05019
ENST00000392905.7 [P05019-4]