TGIF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	16 studies	26% ± 10%	Explore
macrophage	16 studies	23% ± 6%	Explore
basal cell	15 studies	39% ± 15%	Explore
epithelial cell	13 studies	40% ± 17%	Explore
B cell	12 studies	19% ± 3%	Explore
ciliated cell	11 studies	36% ± 15%	Explore
mast cell	9 studies	22% ± 7%	Explore
T cell	8 studies	23% ± 6%	Explore
classical monocyte	8 studies	22% ± 4%	Explore
conventional dendritic cell	7 studies	25% ± 8%	Explore
abnormal cell	7 studies	21% ± 3%	Explore
secretory cell	7 studies	31% ± 9%	Explore
naive B cell	6 studies	22% ± 3%	Explore
memory B cell	6 studies	20% ± 3%	Explore
connective tissue cell	6 studies	25% ± 10%	Explore
endothelial cell	6 studies	27% ± 8%	Explore
myeloid cell	6 studies	27% ± 9%	Explore
gamma-delta T cell	6 studies	20% ± 5%	Explore
pericyte	6 studies	21% ± 8%	Explore
endothelial cell of vascular tree	6 studies	29% ± 7%	Explore
myofibroblast cell	5 studies	21% ± 4%	Explore
type I pneumocyte	5 studies	26% ± 9%	Explore
CD8-positive, alpha-beta T cell	5 studies	19% ± 2%	Explore
regulatory T cell	5 studies	17% ± 1%	Explore
goblet cell	5 studies	25% ± 5%	Explore
mononuclear phagocyte	4 studies	22% ± 5%	Explore
endothelial cell of lymphatic vessel	4 studies	24% ± 8%	Explore
CD4-positive, alpha-beta T cell	4 studies	18% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	27% ± 6%	Explore
smooth muscle cell	4 studies	27% ± 6%	Explore
dendritic cell	4 studies	24% ± 5%	Explore
intestinal crypt stem cell	4 studies	27% ± 7%	Explore
leukocyte	4 studies	25% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
progenitor cell	3 studies	26% ± 6%	Explore
extravillous trophoblast	3 studies	30% ± 5%	Explore
club cell	3 studies	31% ± 2%	Explore
type II pneumocyte	3 studies	27% ± 3%	Explore
luminal cell of prostate epithelium	3 studies	46% ± 7%	Explore
monocyte	3 studies	23% ± 4%	Explore
transit amplifying cell	3 studies	23% ± 6%	Explore
progenitor cell of mammary luminal epithelium	3 studies	18% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	9 studies	25% ± 7%	Explore
peripheral blood	4 studies	19% ± 3%	Explore
placenta	4 studies	24% ± 4%	Explore
prostate	4 studies	39% ± 15%	Explore
breast	4 studies	22% ± 5%	Explore
intestine	4 studies	21% ± 6%	Explore
kidney	3 studies	17% ± 2%	Explore
uterus	3 studies	24% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	100%	2429.25	359 / 359	100%	33.23	286 / 286
lung	100%	3300.54	578 / 578	100%	37.92	1153 / 1155
intestine	100%	2694.16	966 / 966	100%	37.24	526 / 527
prostate	100%	3818.29	245 / 245	100%	29.30	501 / 502
ovary	100%	2835.12	180 / 180	100%	30.82	429 / 430
breast	100%	3284.19	459 / 459	100%	34.29	1114 / 1118
bladder	100%	3130.62	21 / 21	100%	42.09	502 / 504
skin	100%	3979.10	1809 / 1809	100%	29.43	470 / 472
uterus	100%	2780.28	170 / 170	100%	37.50	457 / 459
esophagus	100%	2357.16	1444 / 1445	99%	34.32	182 / 183
thymus	100%	2522.99	653 / 653	99%	36.23	600 / 605
kidney	100%	3037.48	89 / 89	96%	26.98	866 / 901
pancreas	97%	1236.84	318 / 328	94%	30.76	168 / 178
liver	100%	2178.82	225 / 226	85%	15.04	346 / 406
adrenal gland	100%	2338.15	258 / 258	35%	5.55	81 / 230
brain	52%	472.20	1370 / 2642	59%	10.62	419 / 705
adipose	100%	2848.75	1204 / 1204	0%	0	0 / 0
spleen	100%	2514.37	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	28.41	45 / 45
ureter	0%	0	0 / 0	100%	32.49	1 / 1
blood vessel	100%	2490.07	1333 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	29.70	79 / 80
heart	85%	1067.72	735 / 861	0%	0	0 / 0
muscle	82%	1192.52	658 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	79%	15.93	23 / 29
peripheral blood	79%	779.03	736 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0009410	Biological process	response to xenobiotic stimulus
GO_0010629	Biological process	negative regulation of gene expression
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0071363	Biological process	cellular response to growth factor stimulus
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0070410	Molecular function	co-SMAD binding
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0005515	Molecular function	protein binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific

IV. Literature review

[source]

Gene name	TGIF1
Protein name	Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1) TGFB induced factor homeobox 1
Synonyms	TGIF
Description	FUNCTION: Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
Accessions	F8VVS9 ENST00000549253.5 F8VUY0 ENST00000345133.9 [Q15583-4] ENST00000552383.5 ENST00000577543.5 ENST00000551333.1 ENST00000549468.5 ENST00000549780.5 ENST00000401449.5 [Q15583-4] ENST00000546979.5 ENST00000551402.1 F8VX54 ENST00000400167.6 [Q15583-4] F8VYL4 J3KS32 ENST00000551541.5 [Q15583-4] ENST00000343820.10 [Q15583-2] F8VZH2 F8VWK5 ENST00000472042.1 [Q15583-4] ENST00000618001.4 [Q15583-3] ENST00000405385.7 [Q15583-4] ENST00000549546.5 ENST00000407501.6 [Q15583-2] Q15583 ENST00000548489.6 [Q15583-4] ENST00000550958.5 F8VW34 ENST00000330513.10 [Q15583-4] F8VXG3 F8W1J9

TGIF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review