PAWR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097190Biological processapoptotic signaling pathway
GO_2000774Biological processpositive regulation of cellular senescence
GO_0048147Biological processnegative regulation of fibroblast proliferation
GO_0010629Biological processnegative regulation of gene expression
GO_1901300Biological processpositive regulation of hydrogen peroxide-mediated programmed cell death
GO_0050860Biological processnegative regulation of T cell receptor signaling pathway
GO_0010628Biological processpositive regulation of gene expression
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0051017Biological processactin filament bundle assembly
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0006915Biological processapoptotic process
GO_0042986Biological processpositive regulation of amyloid precursor protein biosynthetic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_0030889Biological processnegative regulation of B cell proliferation
GO_0005886Cellular componentplasma membrane
GO_0005884Cellular componentactin filament
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0043522Molecular functionleucine zipper domain binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene namePAWR
Protein nameAlternative protein PAWR
Pro-apoptotic WT1 regulator
PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4)
SynonymsPAR4
DescriptionFUNCTION: Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. .

AccessionsA0A0B4J260
ENST00000550603.1
L8E7E1
F8W1M8
ENST00000551712.1
ENST00000548426.1
ENST00000328827.9
H0YHP5
H0YI16
Q96IZ0
ENST00000552637.1