Name | Number of supported studies | Average coverage | |
---|---|---|---|
pericyte | 27 studies | 29% ± 11% | |
smooth muscle cell | 23 studies | 29% ± 10% | |
endothelial cell | 13 studies | 30% ± 15% | |
basal cell | 13 studies | 32% ± 15% | |
type I pneumocyte | 10 studies | 34% ± 12% | |
epithelial cell | 10 studies | 43% ± 20% | |
ciliated cell | 9 studies | 28% ± 12% | |
fibroblast | 9 studies | 23% ± 11% | |
goblet cell | 7 studies | 35% ± 23% | |
B cell | 6 studies | 22% ± 2% | |
club cell | 6 studies | 34% ± 10% | |
mesothelial cell | 6 studies | 41% ± 13% | |
secretory cell | 6 studies | 25% ± 4% | |
type II pneumocyte | 6 studies | 23% ± 6% | |
respiratory goblet cell | 5 studies | 30% ± 13% | |
myoepithelial cell | 5 studies | 38% ± 16% | |
astrocyte | 5 studies | 31% ± 14% | |
myofibroblast cell | 4 studies | 31% ± 5% | |
retinal pigment epithelial cell | 4 studies | 29% ± 8% | |
endothelial cell of lymphatic vessel | 4 studies | 21% ± 6% | |
luminal cell of prostate epithelium | 4 studies | 29% ± 3% | |
GABAergic neuron | 4 studies | 30% ± 10% | |
oligodendrocyte precursor cell | 4 studies | 21% ± 5% | |
brush cell | 4 studies | 29% ± 11% | |
transit amplifying cell | 4 studies | 34% ± 27% | |
cholangiocyte | 3 studies | 44% ± 20% | |
abnormal cell | 3 studies | 27% ± 15% | |
connective tissue cell | 3 studies | 25% ± 5% | |
luminal hormone-sensing cell of mammary gland | 3 studies | 51% ± 14% | |
hepatocyte | 3 studies | 50% ± 15% | |
muscle cell | 3 studies | 31% ± 7% | |
ependymal cell | 3 studies | 34% ± 16% | |
enteroendocrine cell | 3 studies | 23% ± 4% | |
endothelial cell of vascular tree | 3 studies | 30% ± 12% | |
interneuron | 3 studies | 21% ± 4% | |
kidney distal convoluted tubule epithelial cell | 3 studies | 20% ± 3% | |
parietal epithelial cell | 3 studies | 50% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 4515.91 | 245 / 245 | 100% | 22.54 | 502 / 502 |
lung | 100% | 3678.30 | 576 / 578 | 100% | 19.90 | 1154 / 1155 |
esophagus | 100% | 3903.56 | 1445 / 1445 | 99% | 27.54 | 182 / 183 |
intestine | 100% | 3088.76 | 966 / 966 | 99% | 21.43 | 524 / 527 |
ovary | 100% | 5605.94 | 180 / 180 | 99% | 16.39 | 427 / 430 |
breast | 100% | 4304.76 | 458 / 459 | 99% | 25.24 | 1108 / 1118 |
stomach | 100% | 1852.64 | 359 / 359 | 98% | 19.67 | 281 / 286 |
thymus | 100% | 5156.11 | 653 / 653 | 98% | 19.01 | 594 / 605 |
bladder | 100% | 5238.95 | 21 / 21 | 98% | 18.90 | 494 / 504 |
pancreas | 99% | 1823.79 | 325 / 328 | 97% | 15.10 | 173 / 178 |
uterus | 100% | 8574.36 | 170 / 170 | 96% | 20.73 | 440 / 459 |
kidney | 100% | 3275.07 | 89 / 89 | 96% | 13.30 | 861 / 901 |
liver | 100% | 2135.50 | 226 / 226 | 92% | 11.24 | 374 / 406 |
skin | 100% | 3804.16 | 1801 / 1809 | 49% | 4.31 | 230 / 472 |
adrenal gland | 100% | 1812.58 | 258 / 258 | 29% | 2.29 | 67 / 230 |
blood vessel | 100% | 7308.15 | 1335 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 17.42 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 13.18 | 1 / 1 |
adipose | 100% | 3462.10 | 1199 / 1204 | 0% | 0 | 0 / 0 |
spleen | 94% | 1299.92 | 227 / 241 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 83% | 7.76 | 24 / 29 |
heart | 69% | 797.04 | 597 / 861 | 0% | 0 | 0 / 0 |
brain | 32% | 311.16 | 857 / 2642 | 16% | 1.40 | 115 / 705 |
eye | 0% | 0 | 0 / 0 | 21% | 1.37 | 17 / 80 |
peripheral blood | 19% | 513.03 | 177 / 929 | 0% | 0 | 0 / 0 |
muscle | 5% | 47.34 | 38 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0097190 | Biological process | apoptotic signaling pathway |
GO_2000774 | Biological process | positive regulation of cellular senescence |
GO_0048147 | Biological process | negative regulation of fibroblast proliferation |
GO_0010629 | Biological process | negative regulation of gene expression |
GO_1901300 | Biological process | positive regulation of hydrogen peroxide-mediated programmed cell death |
GO_0050860 | Biological process | negative regulation of T cell receptor signaling pathway |
GO_0010628 | Biological process | positive regulation of gene expression |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0051017 | Biological process | actin filament bundle assembly |
GO_0042130 | Biological process | negative regulation of T cell proliferation |
GO_0006915 | Biological process | apoptotic process |
GO_0042986 | Biological process | positive regulation of amyloid precursor protein biosynthetic process |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0030889 | Biological process | negative regulation of B cell proliferation |
GO_0005886 | Cellular component | plasma membrane |
GO_0005884 | Cellular component | actin filament |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0019899 | Molecular function | enzyme binding |
GO_0043522 | Molecular function | leucine zipper domain binding |
GO_0003714 | Molecular function | transcription corepressor activity |
GO_0005515 | Molecular function | protein binding |
GO_0003779 | Molecular function | actin binding |
Gene name | PAWR |
Protein name | Alternative protein PAWR Pro-apoptotic WT1 regulator PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4) |
Synonyms | PAR4 |
Description | FUNCTION: Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. . |
Accessions | A0A0B4J260 ENST00000550603.1 L8E7E1 F8W1M8 ENST00000551712.1 ENST00000548426.1 ENST00000328827.9 H0YHP5 H0YI16 Q96IZ0 ENST00000552637.1 |