PLAG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010628Biological processpositive regulation of gene expression
GO_0035264Biological processmulticellular organism growth
GO_0060252Biological processpositive regulation of glial cell proliferation
GO_0060736Biological processprostate gland growth
GO_0010629Biological processnegative regulation of gene expression
GO_0006355Biological processregulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0022612Biological processgland morphogenesis
GO_0016607Cellular componentnuclear speck
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePLAG1
Protein nameCHCHD7-PLAG1 fusion protein
Zinc finger protein PLAG1 (Pleiomorphic adenoma gene 1 protein)
Synonyms
DescriptionFUNCTION: Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia. .

AccessionsA7IT79
ENST00000423799.6 [Q6DJT9-2]
ENST00000429357.2 [Q6DJT9-1]
A7IT80
Q6DJT9
ENST00000316981.8 [Q6DJT9-1]