PRKAR1A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	40 studies	34% ± 13%	Explore
fibroblast	38 studies	33% ± 14%	Explore
macrophage	34 studies	28% ± 8%	Explore
natural killer cell	33 studies	27% ± 7%	Explore
pericyte	31 studies	38% ± 15%	Explore
B cell	27 studies	24% ± 8%	Explore
conventional dendritic cell	27 studies	31% ± 10%	Explore
smooth muscle cell	26 studies	32% ± 11%	Explore
classical monocyte	23 studies	32% ± 9%	Explore
T cell	22 studies	22% ± 6%	Explore
non-classical monocyte	21 studies	35% ± 12%	Explore
monocyte	20 studies	29% ± 9%	Explore
CD8-positive, alpha-beta T cell	20 studies	22% ± 5%	Explore
mast cell	19 studies	32% ± 8%	Explore
endothelial cell of lymphatic vessel	19 studies	36% ± 13%	Explore
ciliated cell	19 studies	60% ± 16%	Explore
regulatory T cell	19 studies	24% ± 6%	Explore
memory B cell	18 studies	22% ± 5%	Explore
CD4-positive, alpha-beta T cell	18 studies	21% ± 6%	Explore
basal cell	16 studies	34% ± 15%	Explore
epithelial cell	16 studies	34% ± 18%	Explore
connective tissue cell	16 studies	35% ± 10%	Explore
dendritic cell	15 studies	37% ± 20%	Explore
plasmacytoid dendritic cell	15 studies	31% ± 10%	Explore
gamma-delta T cell	15 studies	29% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	29% ± 6%	Explore
naive B cell	14 studies	24% ± 5%	Explore
mature NK T cell	14 studies	24% ± 5%	Explore
myofibroblast cell	14 studies	31% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	29% ± 7%	Explore
capillary endothelial cell	13 studies	26% ± 9%	Explore
type I pneumocyte	12 studies	36% ± 13%	Explore
type II pneumocyte	12 studies	43% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	25% ± 6%	Explore
club cell	11 studies	32% ± 15%	Explore
vein endothelial cell	11 studies	25% ± 8%	Explore
endothelial cell of vascular tree	11 studies	25% ± 6%	Explore
myeloid cell	11 studies	28% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	23% ± 8%	Explore
endothelial cell of artery	10 studies	27% ± 8%	Explore
mucosal invariant T cell	10 studies	20% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	21% ± 4%	Explore
abnormal cell	9 studies	28% ± 7%	Explore
mesothelial cell	9 studies	30% ± 17%	Explore
glutamatergic neuron	9 studies	39% ± 25%	Explore
secretory cell	8 studies	33% ± 15%	Explore
platelet	8 studies	21% ± 4%	Explore
oligodendrocyte	8 studies	26% ± 6%	Explore
oligodendrocyte precursor cell	8 studies	27% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	18% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	23% ± 5%	Explore
epithelial cell of proximal tubule	7 studies	23% ± 5%	Explore
neuron	7 studies	39% ± 19%	Explore
microglial cell	7 studies	20% ± 5%	Explore
hematopoietic precursor cell	6 studies	25% ± 11%	Explore
plasmablast	6 studies	34% ± 16%	Explore
ionocyte	6 studies	40% ± 10%	Explore
neutrophil	6 studies	25% ± 4%	Explore
respiratory goblet cell	6 studies	28% ± 11%	Explore
leukocyte	6 studies	25% ± 6%	Explore
mononuclear phagocyte	6 studies	31% ± 13%	Explore
kidney loop of Henle epithelial cell	6 studies	30% ± 5%	Explore
renal alpha-intercalated cell	6 studies	41% ± 7%	Explore
innate lymphoid cell	6 studies	30% ± 6%	Explore
astrocyte	6 studies	30% ± 9%	Explore
alveolar macrophage	6 studies	21% ± 5%	Explore
cardiac muscle cell	6 studies	37% ± 11%	Explore
T follicular helper cell	6 studies	23% ± 4%	Explore
GABAergic neuron	6 studies	40% ± 23%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	22% ± 3%	Explore
hematopoietic stem cell	5 studies	22% ± 8%	Explore
precursor B cell	5 studies	31% ± 9%	Explore
pro-B cell	5 studies	26% ± 6%	Explore
retina horizontal cell	5 studies	40% ± 14%	Explore
adipocyte	5 studies	31% ± 16%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	22% ± 4%	Explore
deuterosomal cell	4 studies	22% ± 6%	Explore
exhausted T cell	4 studies	30% ± 2%	Explore
OFF-bipolar cell	4 studies	34% ± 25%	Explore
retinal ganglion cell	4 studies	73% ± 26%	Explore
lymphocyte	4 studies	29% ± 10%	Explore
immature B cell	4 studies	25% ± 5%	Explore
amacrine cell	4 studies	37% ± 14%	Explore
Mueller cell	4 studies	29% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	27% ± 3%	Explore
muscle cell	4 studies	36% ± 8%	Explore
enteroendocrine cell	4 studies	38% ± 21%	Explore
goblet cell	4 studies	26% ± 6%	Explore
interneuron	4 studies	41% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	19% ± 2%	Explore
plasma cell	3 studies	27% ± 14%	Explore
pancreatic A cell	3 studies	48% ± 11%	Explore
type B pancreatic cell	3 studies	37% ± 18%	Explore
glomerular endothelial cell	3 studies	29% ± 5%	Explore
podocyte	3 studies	53% ± 6%	Explore
progenitor cell	3 studies	27% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	40% ± 8%	Explore
retinal bipolar neuron	3 studies	35% ± 9%	Explore
megakaryocyte	3 studies	36% ± 5%	Explore
retinal pigment epithelial cell	3 studies	40% ± 19%	Explore
serous secreting cell	3 studies	31% ± 3%	Explore
tissue-resident macrophage	3 studies	25% ± 3%	Explore
rod bipolar cell	3 studies	25% ± 5%	Explore
germinal center B cell	3 studies	24% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	26% ± 1%	Explore
intermediate monocyte	3 studies	45% ± 22%	Explore
endothelial cell of sinusoid	3 studies	44% ± 36%	Explore
granulocyte	3 studies	36% ± 18%	Explore
glial cell	3 studies	36% ± 21%	Explore
group 3 innate lymphoid cell	3 studies	45% ± 14%	Explore
melanocyte	3 studies	27% ± 7%	Explore
T-helper 17 cell	3 studies	24% ± 8%	Explore
double negative thymocyte	3 studies	26% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	34% ± 13%	Explore
peripheral blood	16 studies	26% ± 8%	Explore
brain	11 studies	32% ± 19%	Explore
kidney	9 studies	27% ± 6%	Explore
intestine	8 studies	23% ± 12%	Explore
eye	8 studies	28% ± 8%	Explore
heart	5 studies	24% ± 3%	Explore
uterus	5 studies	35% ± 15%	Explore
lymph node	5 studies	24% ± 1%	Explore
liver	5 studies	28% ± 12%	Explore
bone marrow	4 studies	23% ± 6%	Explore
adipose	4 studies	22% ± 7%	Explore
breast	4 studies	24% ± 4%	Explore
pancreas	3 studies	37% ± 16%	Explore
adrenal gland	3 studies	23% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	16923.40	459 / 459	100%	147.86	1118 / 1118
esophagus	100%	11264.62	1445 / 1445	100%	84.90	183 / 183
brain	100%	14827.28	2639 / 2642	100%	124.58	705 / 705
lung	100%	15822.25	578 / 578	100%	118.02	1153 / 1155
thymus	100%	14609.99	653 / 653	100%	201.93	603 / 605
bladder	100%	12262.29	21 / 21	100%	87.54	502 / 504
prostate	100%	10898.12	244 / 245	100%	101.07	501 / 502
kidney	100%	10980.94	89 / 89	99%	128.55	894 / 901
uterus	100%	15668.98	170 / 170	99%	97.05	454 / 459
ovary	100%	17743.82	180 / 180	99%	60.12	425 / 430
liver	100%	7148.38	226 / 226	98%	77.35	399 / 406
adrenal gland	100%	15903.42	258 / 258	98%	159.41	225 / 230
intestine	100%	10196.78	965 / 966	98%	69.83	515 / 527
skin	100%	12306.09	1806 / 1809	97%	197.91	460 / 472
stomach	100%	8532.80	359 / 359	97%	64.34	277 / 286
pancreas	88%	3980.39	287 / 328	99%	95.72	176 / 178
adipose	100%	18780.05	1204 / 1204	0%	0	0 / 0
blood vessel	100%	17759.62	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	88.19	29 / 29
muscle	100%	23029.09	803 / 803	0%	0	0 / 0
spleen	100%	10640.05	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	86.94	45 / 45
ureter	0%	0	0 / 0	100%	27.92	1 / 1
heart	99%	22704.07	851 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	99%	131.57	79 / 80
peripheral blood	88%	9440.48	815 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010629	Biological process	negative regulation of gene expression
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0001932	Biological process	regulation of protein phosphorylation
GO_0032024	Biological process	positive regulation of insulin secretion
GO_0060038	Biological process	cardiac muscle cell proliferation
GO_0141162	Biological process	negative regulation of cAMP/PKA signal transduction
GO_0035556	Biological process	intracellular signal transduction
GO_0001707	Biological process	mesoderm formation
GO_0046007	Biological process	negative regulation of activated T cell proliferation
GO_0071377	Biological process	cellular response to glucagon stimulus
GO_0007189	Biological process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0045214	Biological process	sarcomere organization
GO_2000480	Biological process	negative regulation of cAMP-dependent protein kinase activity
GO_0001772	Cellular component	immunological synapse
GO_0098978	Cellular component	glutamatergic synapse
GO_0031594	Cellular component	neuromuscular junction
GO_0016020	Cellular component	membrane
GO_0031588	Cellular component	nucleotide-activated protein kinase complex
GO_0005813	Cellular component	centrosome
GO_0032991	Cellular component	protein-containing complex
GO_0120212	Cellular component	sperm head-tail coupling apparatus
GO_0005930	Cellular component	axoneme
GO_0044853	Cellular component	plasma membrane raft
GO_0005829	Cellular component	cytosol
GO_0005771	Cellular component	multivesicular body
GO_0005737	Cellular component	cytoplasm
GO_0097546	Cellular component	ciliary base
GO_0005952	Cellular component	cAMP-dependent protein kinase complex
GO_0030552	Molecular function	cAMP binding
GO_0004862	Molecular function	cAMP-dependent protein kinase inhibitor activity
GO_0019904	Molecular function	protein domain specific binding
GO_0008603	Molecular function	cAMP-dependent protein kinase regulator activity
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0034236	Molecular function	protein kinase A catalytic subunit binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PRKAR1A
Protein name	Protein kinase cAMP-dependent type I regulatory subunit alpha cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1) Protein kinase A type 1a regulatory subunit Truncated cAMP-dependent protein kinase A type 1A regulatory subunit
Synonyms	TSE1 hCG_28462 PKR1 PRKAR1
Description	FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. . FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. . FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. . FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. . FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. . FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. .
Accessions	K7EMU2 K7EIE5 ENST00000589228.6 [P10644-1] K7EPR5 K7EQK3 ENST00000592800.6 X6RAV4 K7EK41 K7EJ40 ENST00000588178 B2R5T5 ENST00000392711.5 [P10644-1] ENST00000589017 K7EMZ6 ENST00000585981 ENST00000585427.6 [P10644-1] ENST00000536854.6 [P10644-1] P10644 ENST00000711037.1 [P10644-2] ENST00000586397.5 [P10644-1] ENST00000589309.5 K7EPB2 ENST00000585427 ENST00000586541.5 A1XGZ0 ENST00000585608.5 Q96P62 ENST00000589480.6 [P10644-1] ENST00000589480 ENST00000392710.8 ENST00000585981.6 [P10644-2] ENST00000588188.7 [P10644-2] ENST00000358598.6 [P10644-1] K7EM13 K7EKR1 ENST00000589017.6 [P10644-1] ENST00000588178.6 [P10644-1] ENST00000585815.5

PRKAR1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review