RBL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_2000773Biological processnegative regulation of cellular senescence
GO_0030154Biological processcell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0010629Biological processnegative regulation of gene expression
GO_0043550Biological processregulation of lipid kinase activity
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRBL1
Protein nameRB transcriptional corepressor like 1
RBL1 protein
Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)
Synonyms
DescriptionFUNCTION: Key regulator of entry into cell division . Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation . May act as a tumor suppressor . .

AccessionsP28749
ENST00000527999.1
E9PNB6
ENST00000525052.1
Q8WVU8
H0YE05
ENST00000373664.8 [P28749-1]
ENST00000344359.7 [P28749-2]