CHD4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	22 studies	22% ± 7%	Explore
endothelial cell	21 studies	26% ± 10%	Explore
natural killer cell	19 studies	24% ± 7%	Explore
fibroblast	19 studies	20% ± 5%	Explore
macrophage	18 studies	22% ± 7%	Explore
pericyte	18 studies	24% ± 7%	Explore
smooth muscle cell	17 studies	22% ± 5%	Explore
CD8-positive, alpha-beta T cell	15 studies	24% ± 7%	Explore
ciliated cell	13 studies	35% ± 14%	Explore
T cell	12 studies	26% ± 12%	Explore
classical monocyte	12 studies	26% ± 11%	Explore
regulatory T cell	12 studies	22% ± 5%	Explore
gamma-delta T cell	11 studies	27% ± 16%	Explore
mast cell	10 studies	24% ± 6%	Explore
naive B cell	10 studies	24% ± 6%	Explore
CD4-positive, alpha-beta T cell	10 studies	25% ± 6%	Explore
memory B cell	10 studies	21% ± 7%	Explore
astrocyte	10 studies	30% ± 14%	Explore
oligodendrocyte	10 studies	27% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	25% ± 7%	Explore
oligodendrocyte precursor cell	9 studies	26% ± 10%	Explore
plasmacytoid dendritic cell	9 studies	25% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	24% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	22% ± 5%	Explore
epithelial cell	8 studies	36% ± 22%	Explore
connective tissue cell	8 studies	20% ± 3%	Explore
endothelial cell of lymphatic vessel	7 studies	22% ± 4%	Explore
basal cell	7 studies	31% ± 10%	Explore
myofibroblast cell	7 studies	25% ± 6%	Explore
neuron	7 studies	32% ± 12%	Explore
mucosal invariant T cell	7 studies	19% ± 3%	Explore
monocyte	6 studies	22% ± 4%	Explore
leukocyte	6 studies	22% ± 6%	Explore
conventional dendritic cell	6 studies	26% ± 14%	Explore
mature NK T cell	6 studies	20% ± 4%	Explore
abnormal cell	6 studies	27% ± 8%	Explore
type I pneumocyte	5 studies	25% ± 7%	Explore
hematopoietic precursor cell	5 studies	28% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	21% ± 5%	Explore
secretory cell	5 studies	30% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	21% ± 6%	Explore
progenitor cell	5 studies	24% ± 8%	Explore
endothelial cell of artery	5 studies	20% ± 3%	Explore
vein endothelial cell	5 studies	20% ± 2%	Explore
interneuron	5 studies	33% ± 19%	Explore
microglial cell	5 studies	25% ± 7%	Explore
retinal ganglion cell	5 studies	41% ± 25%	Explore
precursor B cell	5 studies	30% ± 6%	Explore
brush cell	5 studies	35% ± 17%	Explore
retina horizontal cell	5 studies	32% ± 13%	Explore
innate lymphoid cell	5 studies	25% ± 9%	Explore
GABAergic neuron	5 studies	29% ± 13%	Explore
glutamatergic neuron	5 studies	41% ± 15%	Explore
deuterosomal cell	4 studies	27% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	27% ± 8%	Explore
non-classical monocyte	4 studies	31% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	28% ± 4%	Explore
hematopoietic stem cell	4 studies	27% ± 4%	Explore
lymphocyte	4 studies	27% ± 11%	Explore
pro-B cell	4 studies	26% ± 2%	Explore
myeloid cell	4 studies	33% ± 8%	Explore
capillary endothelial cell	4 studies	21% ± 3%	Explore
immature B cell	4 studies	24% ± 8%	Explore
amacrine cell	4 studies	31% ± 10%	Explore
endothelial cell of vascular tree	4 studies	21% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	24% ± 7%	Explore
dendritic cell	4 studies	37% ± 15%	Explore
enteroendocrine cell	4 studies	29% ± 8%	Explore
goblet cell	4 studies	22% ± 2%	Explore
type II pneumocyte	3 studies	26% ± 6%	Explore
ionocyte	3 studies	40% ± 9%	Explore
squamous epithelial cell	3 studies	42% ± 22%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	24% ± 4%	Explore
exhausted T cell	3 studies	24% ± 6%	Explore
plasmablast	3 studies	41% ± 21%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	23% ± 3%	Explore
mesothelial cell	3 studies	20% ± 4%	Explore
neural crest cell	3 studies	31% ± 5%	Explore
retinal bipolar neuron	3 studies	31% ± 7%	Explore
ON-bipolar cell	3 studies	20% ± 5%	Explore
rod bipolar cell	3 studies	27% ± 8%	Explore
T follicular helper cell	3 studies	21% ± 3%	Explore
germinal center B cell	3 studies	20% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	18% ± 1%	Explore
granulocyte monocyte progenitor cell	3 studies	22% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	38% ± 16%	Explore
group 3 innate lymphoid cell	3 studies	36% ± 15%	Explore
T-helper 17 cell	3 studies	20% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	9 studies	26% ± 8%	Explore
brain	9 studies	32% ± 12%	Explore
peripheral blood	8 studies	28% ± 14%	Explore
intestine	6 studies	20% ± 6%	Explore
eye	4 studies	24% ± 6%	Explore
liver	4 studies	23% ± 9%	Explore
kidney	3 studies	19% ± 5%	Explore
bone marrow	3 studies	17% ± 1%	Explore
uterus	3 studies	33% ± 17%	Explore
lymph node	3 studies	19% ± 4%	Explore
adipose	3 studies	16% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	14533.81	258 / 258	100%	10.83	230 / 230
bladder	100%	13177.57	21 / 21	100%	11.63	504 / 504
esophagus	100%	11715.29	1445 / 1445	100%	7.48	183 / 183
ovary	100%	12643.03	180 / 180	100%	8.52	430 / 430
skin	100%	15002.32	1809 / 1809	100%	11.68	472 / 472
thymus	100%	15351.88	653 / 653	100%	19.27	605 / 605
uterus	100%	14317.73	170 / 170	100%	14.43	459 / 459
brain	100%	8192.94	2637 / 2642	100%	10.07	705 / 705
intestine	100%	13020.41	966 / 966	100%	7.91	526 / 527
prostate	100%	10067.80	245 / 245	100%	7.10	501 / 502
pancreas	100%	6999.42	327 / 328	100%	9.23	178 / 178
breast	100%	10932.61	459 / 459	100%	10.61	1113 / 1118
lung	100%	11624.07	578 / 578	99%	7.89	1149 / 1155
kidney	100%	9590.99	89 / 89	99%	7.39	896 / 901
liver	100%	5233.74	225 / 226	99%	6.73	403 / 406
stomach	100%	10052.62	359 / 359	99%	6.80	282 / 286
adipose	100%	10915.83	1204 / 1204	0%	0	0 / 0
blood vessel	100%	13095.96	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	9.91	80 / 80
lymph node	0%	0	0 / 0	100%	19.64	29 / 29
muscle	100%	9143.01	803 / 803	0%	0	0 / 0
spleen	100%	12938.55	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	8.58	45 / 45
ureter	0%	0	0 / 0	100%	13.24	1 / 1
heart	98%	8674.52	845 / 861	0%	0	0 / 0
peripheral blood	95%	9236.94	880 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010629	Biological process	negative regulation of gene expression
GO_2000736	Biological process	regulation of stem cell differentiation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006338	Biological process	chromatin remodeling
GO_0000724	Biological process	double-strand break repair via homologous recombination
GO_0042659	Biological process	regulation of cell fate specification
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0051963	Biological process	regulation of synapse assembly
GO_0072553	Biological process	terminal button organization
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0016020	Cellular component	membrane
GO_0005813	Cellular component	centrosome
GO_0150048	Cellular component	cerebellar granule cell to Purkinje cell synapse
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0090734	Cellular component	site of DNA damage
GO_0090575	Cellular component	RNA polymerase II transcription regulator complex
GO_0005737	Cellular component	cytoplasm
GO_0016581	Cellular component	NuRD complex
GO_0000781	Cellular component	chromosome, telomeric region
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0004386	Molecular function	helicase activity
GO_0042393	Molecular function	histone binding
GO_0003682	Molecular function	chromatin binding
GO_0001221	Molecular function	transcription coregulator binding
GO_0031492	Molecular function	nucleosomal DNA binding
GO_0003714	Molecular function	transcription corepressor activity
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0008270	Molecular function	zinc ion binding
GO_0005524	Molecular function	ATP binding
GO_0140658	Molecular function	ATP-dependent chromatin remodeler activity
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity
GO_0042826	Molecular function	histone deacetylase binding

IV. Literature review

[source]

Gene name	CHD4
Protein name	Chromodomain helicase DNA binding protein 4 Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) CHD4 protein DNA helicase (EC 3.6.4.12)
Synonyms
Description	FUNCTION: ATP-dependent helicase that binds and distorts nucleosomal DNA . Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin . Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination . Involved in neurogenesis (By similarity). .
Accessions	ENST00000642893.1 A0A2R8Y5M9 A0A2R8Y7I0 ENST00000644132.1 ENST00000357008.7 A0A2R8Y212 ENST00000644352.1 ENST00000644077.1 Q05CG6 A0A2R8Y8C1 A0A2R8YFK9 A0A2R8Y4X2 A0A2R8YDJ9 ENST00000645005.1 ENST00000645143.1 A0A2R8Y5J0 ENST00000644801.1 ENST00000643815.1 ENST00000646608.1 A0A2R8Y539 ENST00000644652.1 ENST00000645022.1 A0A2R8Y5Z7 ENST00000545584.2 Q14839 A0A2R8YFD8 ENST00000642594.1 F5GWX5 ENST00000646462.1 ENST00000642637.1 A0A0C4DGG9 A0A2R8Y795 A0A2R8Y6G9 ENST00000642879.1 ENST00000645991.1 ENST00000644137.1 ENST00000644289.1 ENST00000643335.1 ENST00000643538.1 A0A2R8Y685 A0A2R8YD40 A0A2U3TZM0 F5H596 ENST00000647483.1 A0A2R8Y7X1 A0A2R8Y512 F5H6N4 A0A2R8YER1 A0A2R8Y521 ENST00000545942.6 ENST00000645095.1 [Q14839-2] ENST00000646806.1 A0A2R8YE38 ENST00000646268.1 A0A2R8Y425 ENST00000642810.1 ENST00000645645.1 A0A2R8YDW2 A0A2R8Y8B3 ENST00000544040.7 [Q14839-1] ENST00000544484.6 A0A2R8Y7M9

CHD4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review