Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 17 studies | 26% ± 8% | |
| endothelial cell of artery | 12 studies | 31% ± 13% | |
| capillary endothelial cell | 10 studies | 20% ± 5% | |
| endothelial cell of vascular tree | 3 studies | 28% ± 10% | |
| goblet cell | 3 studies | 19% ± 0% |
Insufficient scRNA-seq data for expression of DLL4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 2780.76 | 652 / 653 | 98% | 19.31 | 594 / 605 |
| lung | 100% | 3803.85 | 576 / 578 | 97% | 12.55 | 1118 / 1155 |
| breast | 100% | 3688.39 | 459 / 459 | 96% | 10.47 | 1074 / 1118 |
| intestine | 94% | 1179.96 | 909 / 966 | 98% | 17.94 | 518 / 527 |
| bladder | 100% | 1466.24 | 21 / 21 | 92% | 11.20 | 464 / 504 |
| kidney | 99% | 1416.31 | 88 / 89 | 85% | 43.91 | 767 / 901 |
| prostate | 94% | 1390.25 | 231 / 245 | 86% | 7.67 | 433 / 502 |
| uterus | 100% | 2275.19 | 170 / 170 | 73% | 6.16 | 333 / 459 |
| esophagus | 80% | 889.71 | 1158 / 1445 | 90% | 10.15 | 165 / 183 |
| stomach | 70% | 565.87 | 251 / 359 | 98% | 16.47 | 280 / 286 |
| brain | 83% | 648.89 | 2193 / 2642 | 60% | 4.73 | 421 / 705 |
| skin | 62% | 577.86 | 1115 / 1809 | 79% | 7.39 | 374 / 472 |
| ovary | 67% | 602.48 | 120 / 180 | 70% | 4.32 | 303 / 430 |
| adrenal gland | 42% | 309.40 | 108 / 258 | 93% | 21.19 | 213 / 230 |
| pancreas | 27% | 163.09 | 88 / 328 | 99% | 14.70 | 176 / 178 |
| liver | 30% | 198.11 | 68 / 226 | 90% | 8.67 | 365 / 406 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.72 | 1 / 1 |
| adipose | 100% | 4069.94 | 1199 / 1204 | 0% | 0 | 0 / 0 |
| heart | 99% | 1775.12 | 851 / 861 | 0% | 0 | 0 / 0 |
| muscle | 96% | 931.37 | 769 / 803 | 0% | 0 | 0 / 0 |
| spleen | 86% | 718.98 | 207 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 6.33 | 37 / 45 |
| blood vessel | 76% | 866.32 | 1019 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 72% | 5.08 | 21 / 29 |
| eye | 0% | 0 | 0 / 0 | 60% | 10.13 | 48 / 80 |
| peripheral blood | 2% | 8.26 | 15 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0090051 | Biological process | negative regulation of cell migration involved in sprouting angiogenesis |
| GO_0007601 | Biological process | visual perception |
| GO_0001525 | Biological process | angiogenesis |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_1903588 | Biological process | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| GO_0001974 | Biological process | blood vessel remodeling |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0007165 | Biological process | signal transduction |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0003180 | Biological process | aortic valve morphogenesis |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0003344 | Biological process | pericardium morphogenesis |
| GO_0003208 | Biological process | cardiac ventricle morphogenesis |
| GO_0030217 | Biological process | T cell differentiation |
| GO_0001569 | Biological process | branching involved in blood vessel morphogenesis |
| GO_0003209 | Biological process | cardiac atrium morphogenesis |
| GO_2000179 | Biological process | positive regulation of neural precursor cell proliferation |
| GO_0061074 | Biological process | regulation of neural retina development |
| GO_0035912 | Biological process | dorsal aorta morphogenesis |
| GO_0010596 | Biological process | negative regulation of endothelial cell migration |
| GO_0050767 | Biological process | regulation of neurogenesis |
| GO_0045747 | Biological process | positive regulation of Notch signaling pathway |
| GO_0045746 | Biological process | negative regulation of Notch signaling pathway |
| GO_0003222 | Biological process | ventricular trabecula myocardium morphogenesis |
| GO_0035924 | Biological process | cellular response to vascular endothelial growth factor stimulus |
| GO_0060579 | Biological process | ventral spinal cord interneuron fate commitment |
| GO_0044344 | Biological process | cellular response to fibroblast growth factor stimulus |
| GO_0072554 | Biological process | blood vessel lumenization |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0048018 | Molecular function | receptor ligand activity |
| GO_0005112 | Molecular function | Notch binding |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DLL4 |
| Protein name | Delta-like protein Delta-like protein 4 (Drosophila Delta homolog 4) (Delta4) |
| Synonyms | UNQ1895/PRO4341 |
| Description | FUNCTION: Involved in the Notch signaling pathway as Notch ligand . Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting . Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate . . FUNCTION: Putative Notch ligand involved in the mediation of Notch signaling. . |
| Accessions | A0A292G9B9 Q9NR61 ENST00000249749.7 |
