AKIRIN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050871Biological processpositive regulation of B cell activation
GO_0010629Biological processnegative regulation of gene expression
GO_0045087Biological processinnate immune response
GO_0051147Biological processregulation of muscle cell differentiation
GO_0009792Biological processembryo development ending in birth or egg hatching
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045089Biological processpositive regulation of innate immune response
GO_0002250Biological processadaptive immune response
GO_0071630Biological processnuclear protein quality control by the ubiquitin-proteasome system
GO_0031144Biological processproteasome localization
GO_0006606Biological processprotein import into nucleus
GO_0002821Biological processpositive regulation of adaptive immune response
GO_0042742Biological processdefense response to bacterium
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0021987Biological processcerebral cortex development
GO_0032496Biological processresponse to lipopolysaccharide
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0042802Molecular functionidentical protein binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAKIRIN2
Protein nameAkirin-2
SynonymsC6orf166
DescriptionFUNCTION: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development . Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore . Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity). .

AccessionsENST00000257787.6
Q53H80