XDH | OmnibusX

Name	Number of supported studies	Average coverage
enterocyte	4 studies	22% ± 6%	Explore
squamous epithelial cell	3 studies	25% ± 5%	Explore
epithelial cell	3 studies	42% ± 23%	Explore
hepatocyte	3 studies	45% ± 11%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of XDH at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	5636.15	226 / 226	87%	26.13	355 / 406
prostate	87%	411.68	212 / 245	63%	4.02	318 / 502
intestine	52%	1378.48	499 / 966	88%	13.60	466 / 527
esophagus	40%	980.81	583 / 1445	92%	17.48	169 / 183
pancreas	37%	42.09	122 / 328	88%	14.00	157 / 178
bladder	48%	254.05	10 / 21	77%	8.81	388 / 504
breast	61%	555.98	278 / 459	50%	8.98	561 / 1118
stomach	18%	46.00	66 / 359	79%	9.85	226 / 286
skin	88%	258.98	1589 / 1809	4%	0.26	19 / 472
lung	13%	15.27	76 / 578	78%	10.77	901 / 1155
tonsil	0%	0	0 / 0	87%	9.02	39 / 45
uterus	5%	6.17	8 / 170	63%	8.89	287 / 459
thymus	37%	54.95	244 / 653	19%	1.33	116 / 605
ovary	0%	0	0 / 180	50%	3.46	213 / 430
kidney	26%	44.67	23 / 89	12%	1.24	109 / 901
muscle	20%	90.58	161 / 803	0%	0	0 / 0
adipose	10%	10.77	118 / 1204	0%	0	0 / 0
adrenal gland	0%	0.38	1 / 258	3%	0.29	6 / 230
blood vessel	1%	0.71	8 / 1335	0%	0	0 / 0
spleen	0%	4.47	1 / 241	0%	0	0 / 0
heart	0%	0.24	2 / 861	0%	0	0 / 0
brain	0%	0.09	3 / 2642	0%	0	0 / 705
peripheral blood	0%	0.30	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006919	Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0009114	Biological process	hypoxanthine catabolic process
GO_0006204	Biological process	IMP catabolic process
GO_0006161	Biological process	deoxyguanosine catabolic process
GO_0010629	Biological process	negative regulation of gene expression
GO_0006196	Biological process	AMP catabolic process
GO_0006157	Biological process	deoxyadenosine catabolic process
GO_0046038	Biological process	GMP catabolic process
GO_0000255	Biological process	allantoin metabolic process
GO_0006149	Biological process	deoxyinosine catabolic process
GO_0006147	Biological process	guanine catabolic process
GO_1900745	Biological process	positive regulation of p38MAPK cascade
GO_0045602	Biological process	negative regulation of endothelial cell differentiation
GO_0051898	Biological process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0046059	Biological process	dAMP catabolic process
GO_0001933	Biological process	negative regulation of protein phosphorylation
GO_0043605	Biological process	amide catabolic process
GO_0001937	Biological process	negative regulation of endothelial cell proliferation
GO_0016226	Biological process	iron-sulfur cluster assembly
GO_2000379	Biological process	positive regulation of reactive oxygen species metabolic process
GO_0006154	Biological process	adenosine catabolic process
GO_0009115	Biological process	xanthine catabolic process
GO_0006148	Biological process	inosine catabolic process
GO_0046055	Biological process	dGMP catabolic process
GO_2001213	Biological process	negative regulation of vasculogenesis
GO_1900747	Biological process	negative regulation of vascular endothelial growth factor signaling pathway
GO_0007595	Biological process	lactation
GO_0005615	Cellular component	extracellular space
GO_0005777	Cellular component	peroxisome
GO_0005829	Cellular component	cytosol
GO_0016529	Cellular component	sarcoplasmic reticulum
GO_0042803	Molecular function	protein homodimerization activity
GO_0050660	Molecular function	flavin adenine dinucleotide binding
GO_0071949	Molecular function	FAD binding
GO_0004855	Molecular function	xanthine oxidase activity
GO_0005506	Molecular function	iron ion binding
GO_0043546	Molecular function	molybdopterin cofactor binding
GO_0070675	Molecular function	hypoxanthine oxidase activity
GO_0070674	Molecular function	hypoxanthine dehydrogenase activity
GO_0051537	Molecular function	2 iron, 2 sulfur cluster binding
GO_0004854	Molecular function	xanthine dehydrogenase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	XDH
Protein name	Xanthine dehydrogenase/oxidase Uncharacterized protein XDH Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)]
Synonyms	XDHA
Description	FUNCTION: Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). .
Accessions	Q585T6 ENST00000379416.4 P47989 A0AA96C912

XDH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review